36601-68-0Relevant academic research and scientific papers
N-heterocyclic carbene-catalyzed cross-coupling of aromatic aldehydes with activated alkyl halides
Padmanaban, Mohan,Biju, Akkattu T.,Glorius, Frank
supporting information; experimental part, p. 98 - 101 (2011/03/19)
N-Heterocyclic carbene-catalyzed umpolung of aldehydes followed by their interception with diarylbromomethanes has been reported. This conceptually novel transition-metal-free cross-coupling of aldehydes with alkyl halides works well at low catalyst loadings and under mild reaction conditions leading to the formation of diaryl acetophenone derivatives in good yields. In addition, α-halo ketones and esters can also be used as aldehyde reaction partners.
Novel tele nucleophilic aromatic substitutions in α-(benzotriazol-1-yl)alkyl aryl ketones
Katritzky, Alan R.,Wu, Hong,Xie, Linghong
, p. 903 - 906 (2007/10/03)
Reactions of α-(benzoltriazol-1-yl)alkyl aryl ketones 2 with alkyllithiums or Grignard reagents afforded para-alkylated products 5 via novel tele nucleophilic, aromatic substitutions.
