36610-32-9

Upstream product

• 383-63-1 ethyl trifluoroacetate, 
• 1730-25-2 allylmagnesium bromide 
• 106-95-6 allyl bromide 
• 407-25-0 trifluoroacetic anhydride 
• 762-72-1 allyl-trimethyl-silane 

Downstream Products

• 22253-59-4 1-oxido-4-(trifluoromethyl)pyridin-1-ium 
• 39890-98-7 2,6-dichloro-4-(trifluoromethyl)pyridine 
• 81565-18-6 2-chloro-4-trifluoromethyl pyridine 
• 3796-24-5 4-trifluoromethylpyridine 

Relevant academic research and scientific papers

Preparation of trifluoromethyl-substituted alcohols from allylsilanes and trifluoroacetic anhydride

The titanium tetrachloride-mediated addition of allyltrimethylsilane or 1,8-bis(trimethylsilyl)-2,6-octadiene and trifluoroacetic anhydride led to trifluoromethyldiallylcarbinol or (dl)-1-trifluoromethyl-2,5- divinylcyclopentanol, respectively, in fair yields; this latter was further converted into several 1-trifluoromethyl-2-vinylcyclopentane derivatives.

Convenient approaches to 4-trifluoromethylpyridine

A number of approaches to the synthesis of 2-chloro-and 2,6-dichloro-4-trifluoromethylpyridine are described. The first method for 2-chloro-and 2,6-dichloro-4-trifluoromethylpyridine is based on commercially available ethyl trifluoroacetate. An alternative access to 2,6-dichloro-4-trifluoromethyl pyridine uses trifluoroacetaldehyde as starting material. 2-Chloro-4-trifluoromethylpyridine is prepared from ethyl(trifluoroacetylvinyl)ether in two steps.

Synthesis and antitumor evaluation of novel monoindolyl-4-trifluoromethylpyridines and bisindolyl-4-trifluoromethylpyridines

A series of novel monoindolyl-4-trifluoromethylpyridines and bisindolyl-4-trifluoromethylpyridines was designed and synthesized as potential antitumor agents. They were evaluated for preliminary cytotoxic activity against P388 and A-549 cells with IC50 values. 4-Trifluoromethyl-2,6-bis[3′-(N-tosyl-6′-methoxyl-indolyl)] pyridine was identified as the most potent in this series.

Cholesterol biosynthesis inhibitors

Cholesterol biosynthesis inhibitors are described which are derivatives of coenzyme A having the general formula STR1 wherein n is 1 to 3, inclusive, and CoA is coenzyme A minus a hydrogen atom from a sulfhydryl substituent. They are produced by reacting coenzyme A with a fluorinated 3-hydroxy-3-methylglutaric anhydride of the general formula STR2 in dilute aqueous alkali.