3663-21-6

Basic information

• Product Name: N-(4-butyl-2-nitrophenyl)acetamide
• Synonyms: N-(4-butyl-2-nitrophenyl)acetamide;N-(4-butyl-2-nitrophenyl)acetamide C12H16N2O3 236.27
• CAS NO: 3663-21-6
• Molecular Formula: C₁₂H₁₆N₂O₃
• Molecular Weight: 236.26704
• EINECS: 222-915-6
• Mol File: 3663-21-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 425.7 °C at 760 mmHg
• Flash Point: 211.3 °C
• Appearance: /
• Density: 1.18 g/cm³
• Vapor Pressure: 1.87E-07mmHg at 25°C
• Refractive Index: 1.572
• CAS DataBase Reference: N-(4-butyl-2-nitrophenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-butyl-2-nitrophenyl)acetamide(3663-21-6)
• EPA Substance Registry System: N-(4-butyl-2-nitrophenyl)acetamide(3663-21-6)

Safety Data

• Hazardous Substances Data: 3663-21-6(Hazardous Substances Data)

Usage

General Description

N-(4-butyl-2-nitrophenyl)acetamide is a chemical compound with the molecular formula C12H15N3O. It is an acetamide derivative that contains a butyl group and a nitrophenyl group. N-(4-butyl-2-nitrophenyl)acetamide has potential biological activity and may be used in pharmaceutical research and drug development. Its structure and properties make it suitable for studying its interactions with biological systems and potential therapeutic applications. Further research is necessary to fully understand its pharmacological and toxicological properties and potential uses in medicine.

InChI:InChI=1/C12H16N2O3/c1-3-4-5-10-6-7-11(13-9(2)15)12(8-10)14(16)17/h6-8H,3-5H2,1-2H3,(H,13,15)

Upstream product

• 62-53-3 aniline 
• 1126-78-9 N-(n-butyl)aniline 
• 104-13-2 4-Butylaniline 
• 3663-20-5 N-(4-butylphenyl)acetamide 
• 7697-37-2 nitric acid 
• 64-19-7 acetic acid 
• 104-51-8 1-butylbenzene 
• 20651-75-6 1-butyl-4-nitro-benzene 

Downstream Products

• 3663-24-9 5-n-butyl-1H-benzotriazole 
• 5369-17-5 m-(n-butyl)-aniline 
• 20651-76-7 1-butyl-3-nitro-benzene 
• 3663-23-8 4-n-butyl-1,2-phenylenediamine 
• 143621-51-6 4-n-butyl-2-nitrobenzaldehyde 
• 35198-79-9 C₁₅H₂₁N₃O₃S 
• 3663-22-7 4-n-butyl-2-nitroaniline 

Relevant articles and documents

5-n-butyl-1H-benzotriazole synthesis process

The present invention discloses a 5-n-butyl-1H-benzotriazole synthesis process, which comprises: adding concentrated sulfuric acid to acetic anhydride in a dropwise manner, and adding 4-n-butyl aniline in a dropwise manner to prepare 4-n-butyl acetanilide; adding a mixed acid solution comprising 65% concentrated nitric acid and acetic anhydride to the 4-n-butyl acetanilide in a dropwise manner to synthesize 4-n-butyl-2-nitro acetanilide; synthesizing 4-n-butyl-2-nitroaniline by using the 4-n-butyl-2-nitro acetanilide, 95% ethanol and 40% sodium hydroxide as raw materials; under the effect of a catalyst, using the 4-n-butyl-2-nitroaniline and dehydrated alcohol and sequentially using nitrogen and hydrogen to convert under a closed condition to prepare 4-n-butyl-o-phenylenediamine; and adding the 4-n-butyl-o-phenylenediamine, water and sodium nitrite to an autoclave to synthesize the 5-n-butyl-1H-benzotriazole. According to the present invention, the process equipment is simple, and the product yield is high.

Photochemistry of (2-nitrophenyl)diazomethane studied by the matrix isolation technique. (Nitrophenyl)carbene to (carboxylphenyl)nitrene rearrangement by successive reduction of the nitro group with the carbenic center

Irradiation (λ > 350 nm) of (2-nitrophenyl)diazomethane (1) matrix-isolated in Ar at 10 K provided 2-nitrosobenzaldehyde (3) presumably as a result of intramolecular oxygen migration in (2-nitrophenyl)carbene (2). Upon further irradiation (λ > 350 nm), 3 was decomposed to give a mixture of 2,1-benzisoxazol-3(1H)-one (4) and carbonylcyclopentadiene imine (5) along with CO2. The oxazolone (4) underwent decarboxylation to give 5 upon irradiation with shorter wavelength light (λ > 300 nm) but not at longer wavelength (λ > 350 nm), suggesting 4 is not the direct precursor for 5 in the photolysis of 3. Irradiation (λ > 350 nm) of (4-n-butyl-2-nitrophenyl)diazomethane (1b) under similar conditions resulted in the formation of carbonyloximinocyclohexadienylidene (7) which then produced the oxazolone (4b) and the imine (5b) upon further irradiation, suggesting that a 1,4-biradical generated as a result of abstraction of H at the ortho position by the photoexcited nitroso group was involved in the reaction of 3 forming 4. (2-Carboxyphenyl)nitrene (9) generated by 1,4-OH shift in the 1,4-biradical was postulated as an intermediate leading to 5, and this was actually demonstrated by independent generation of 9 by the photolysis of 2-azidobenzoic acid (8).

Treatment of helminth infections with substituted phenyl-thiourea derivatives

Benzene derivatives of the formula:- STR1 wherein R is an aliphatic hydrocarbon group of 1 to 4 carbon atoms optionally substituted by halogen or alkoxy, R1 is hydrogen or methyl, R2 is hydrogen, halogen, alkyl, alkanoylamino optionally substituted by cycloalkyl of 3 to 6 carbon atoms, alkoxycarbonylamino, alkanoyl, benzoyl or N-methylmethanesulphonylamino, and Y is primary amino or substituted amino, possess anthelmintic and anti-viral activity. New compounds within that formula possess fungicidal properties.