3663-46-5

Usage

Uses

Used in Food and Beverage Industry:
(2,2,5-Trimethyl-[1,3]dioxan-5-yl)methanol is used as a flavoring agent for its minty taste and aroma, particularly in the production of mint-flavored products.
Used in Perfume and Cosmetic Industry:
(2,2,5-Trimethyl-[1,3]dioxan-5-yl)methanol is used as a fragrance ingredient in perfumes and other cosmetic products due to its pleasant minty aroma.
Safety Precautions:
It should be handled with care and in accordance with safety guidelines due to its flammable and potentially hazardous properties.

InChI:InChI=1/C8H16O3/c1-7(2)10-5-8(3,4-9)6-11-7/h9H,4-6H2,1-3H3

Upstream product

• 77-85-0 2-(hydroxymethyl)-2-methylpropane-1,3-diol 
• 67-64-1 acetone 
• 100-02-7 4-nitro-phenol 
• 151134-14-4 2-(2-chloro-5-methyl-1,3,2-dioxaphosphorinan-5-yl2-sulfide)methoxyacetic acid, methyl ester 
• 77-76-9 2,2-dimethoxy-propane 

Downstream Products

• 138517-53-0 5-(2,2,5-trimethyl-1,3-dioxane)carbaldehyde 
• 77-85-0 2-(hydroxymethyl)-2-methylpropane-1,3-diol 
• 151801-11-5 3-benzyloxymethyl-3-methyl-1,5,8,11-tetraoxacyclotridecane 
• 151801-12-6 3-(7-benzyloxy-2,5-dioxaheptyl)-3-methyl-1,5,8,11-tetraoxacyclotridecane 
• 87104-93-6 10-Benzyloxymethyl-10-methyl-2,5,8,12,15,18-hexaoxanonadecan 
• 87104-79-8 18-Benzyloxymethyl-18-methyl-1,4,7,10,13,16-hexaoxacyclononadecan 
• 1433995-47-1 C₅₇H₁₀₀O₉ 
• 1424713-00-7 C₄₅H₈₄O₉ 
• 1424713-02-9 C₆₉H₁₁₆O₉ 
• 612846-83-0 ((2S,4R,5R)-4-Allyl-5-methyl-2-phenyl-[1,3]dioxan-5-yl)-methanol 
• 87104-70-9 5-<(benzyloxy)methyl>-2,2,5-trimethyl-1,3-dioxane 
• 34541-77-0 1,3-(dimethylmethylenedioxy)-2-methyl-2-(methylene-p-toluenesulfonyl)propane 
• 1452877-23-4 (2,2,5-trimethyl-1,3-dioxan-5-yl)methyl 1-(iodomethyl)-2-oxocyclohexanecarboxylate 

Relevant academic research and scientific papers

New organofunctional cyclophosphazene derivatives

The rational design, synthesis and polymerization of the methacrylphosphazenes N3P3Cl5O(CHR)x(CHR′) yOC(O)CMe=CH2 (x=y=1,2, R=R′=H; x=1, R=Me, y=1, R′=H; x=1, R=H, y=1, R′=Me) is reported. Another new type of alkenyloxy derivative is prepared from 5-nonbornene-2-methoxide and N3P3Cl5. The preparation of spirocyclic derivatives with methacrylate or protected hydroxyl groups is reported Various functionalized ferrocene derivatives of the cyclophosphazenes have been prepared with particular attention being paid to the synthesis and electrochemical characterization of the N3P3Cl6-n(NMeCH2C5H 4FeC5H5)n(n=1,2,3,4) series.

Comb-Like Amphiphilic Polycarbonates with Different Lengths of Cationic Branches for Enhanced siRNA Delivery

Owing to the biodegradability and good biocompatibility polycarbonates show the versatile class of applications in biomedical fields. While their poor functional ability seriously limited the development of functional polycarbonates. Herein, a new Br-containing cyclic carbonate (MTC-Br) and a polycarbonate atom transfer radical polymerization (ATRP) macro-initiator (PEG-PMTC-Br) is synthesized. Then, by initiating the side-chain ATRP of 2-(dimethyl amino)ethyl methacrylate (DMAEMA) on PEG-PMTC-Br, a series of comb-like amphiphilic cationic polycarbonates, PEG-b-(PMTC-g-PDMAEMA) (GMDMs), with different lengths of cationic branches are successfully prepared. All these poly(ethylene glycol)-b-(poly((5-methyl-2-oxo-1,3-dioxane-5-yl) methyl 2-bromo-2-methylpropanoate/1,3-dioxane-2-one)-g-poly(2-dimethyl aminoethyl methacrylate) (GMDMs) self-assembled nanoparticles (NPs) (≈180 nm, +40 mV) can well bind siRNA to form GMDM/siRNA NPs. The gene silence efficiency of GMDM/siRNA high to 80percent, which is even higher than the commercial transfection reagent lipo2000 (76percent). But GMDM/siRNA shows lower cell uptake than lipo2000. So, the high gene silence ability of GMDM/siRNA NPs can be attributed to the strong intracellular siRNA trafficking capacity. Therefore, GMDM NPs are potential siRNA vectors and the successful preparation of comb-like polycarbonates also provides a facile way for diverse side-chain functional polycarbonates, expanding the application of polycarbonates.

Electrospun poly(l -lactide-co -acryloyl carbonate) fiber scaffolds with a mechanically stable crimp structure for ligament tissue engineering

The aim of this study was to prepare a fibrous scaffold that possesses a crimped morphology using a photo-cross-linkable biodegradable copolymer. To obtain the crimped morphology, the polymer was first electrospun onto a rotating wire mandrel to obtain aligned straight fibers. Postprocessing by immersion in aqueous buffer at 37 °C generated a crimplike pattern in the fibers. It was reasoned that cross-linking the fibers following formation of the crimped structure would endow the scaffolds with a recoverable crimp pattern and mechanical properties similar to that of the collagen fibers in the anterior cruciate ligament (ACL). To achieve this aim, a trimethylene carbonate based monomer bearing an acrylate pendant group was synthesized and copolymerized with l-lactide. The copolymer was electrospun and photo-cross-linked yielding fibrous scaffolds possessing a substantial increase in tensile modulus and crimp stability compared to the uncross-linked fibrous scaffolds. The crimp-stabilized scaffolds also showed good cytocompatibility toward 3T3 fibroblasts, which attached and grew along the crimped fibers. These findings suggest that these cross-linked fiber scaffolds may be useful for the generation of cultured ligament tissue.

CLEAVABLE MULTI-ALCOHOL-BASED MICROCAPSULES

The present invention relates to a new process for the preparation of microcapsules based on cleavable multi-alcohols. Cleavable multi-alcohol-based microcapsules are also an object of the invention. Perfuming compositions and consumer products comprising

IMIDAZO[4,5-C]PYRIDINE DERIVATIVES AS TOLL-LIKE RECEPTOR AGONSITS

The present invention relates to imidazo-pyridinyl compounds, or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject.

COMPOUNDS FOR MODIFICATION OF NEGATIVELY CHARGED CARRIER SURFACE, METHOD OF THEIR PREPARATION AND USE THEREOF

The present invention relates to compounds of general formula (I) (I) wherein Cg is -CH2-C≡CH or -CH2-CH=CH2; R is independently selected from the group consisting of (Cl-C6)alkyl, which may be linear or branched; (C5-C6)c

POLYMER-PARTICLE LIGHT-CLEAVABLE CARRIER SYSTEMS FOR PHOTODYNAMIC THERAPY

The present invention generally relates to the formation, chemistry and application of biologically active compositions. More particularly, the present invention relates to certain dyes, specifically porphyrin and chlorin derivatives, in combination with

LINOLEIC ACID DERIVATIVES, PHARMACEUTICAL COMPOSITION OR FOOD COMPOSITION COMPRISING SAID LINOLEIC ACID DERIVATIVES, AND THEIR USES

This invention relates to linoleic acid derivative of Formula (I) below comprising a hydrophobic part C17H31 linked to a polar head part "A": wherein said polar head part A is selected from A1 to A4 below: wherein R1 and R2 are independently selected from the group composed of H or a saturated or unsaturated, straight or branched alkyl group containing 1 to 8 carbon atoms, or R1 and R2 are linked together to form a divalent radical of formula -R1-R2-, wherein -R1-R2- is preferably -CH2-CH2- or-(CH2)3-; R3 is independently selected from the group composed of:

IMMUNOGENIC TREHALOSE COMPOUNDS AND USES THEREOF

Disclosed herein are immunogenic trehalose compounds and methods of use thereof, for example as vaccine adjuvants.

Cyclic carbonate monomer capable of initiating ATRP polymerization, and preparation method and application thereof

The invention relates to a cyclic carbonate monomer capable of initiating ATRP polymerization, and a preparation method and an application thereof. The preparation method comprises the following steps: preparing (5-methyl-2,2-dimethyl-1,3-dioxane-5-yl)methanol from trimethylolethane and acetone; preparing (5-methyl-2,2-dimethyl-1,3-dioxane-5-yl)methyl-2-bromo-2-methylpropionate from bromoisobutyryl bromide and the (5-methyl-2,2-dimethyl-1,3-dioxane-5-yl)methanol; treating the (5-methyl-2,2-dimethyl-1,3-dioxane-5-yl)methyl-2-bromo-2-methylpropionate in concentrated hydrochloric acid so as to prepare 2,2-hydroxymethyl propyl bromoisobutyrate; and allowing the 2,2-hydroxymethyl propyl bromoisobutyrate to react with ethyl chloroformate so as to obtain methyl-2-bromo-2-methyl(5-(5-methyl-2-carbonyl-1,3-dioxane)yl)propionate. According to the invention, ring-opening polymerization can be performed to prepare a polycarbonate ATRP macromolecular initiator which is further used for initiating ATRP polymerization of an allyl monomer on a polycarbonate skeleton; and various functional polycarbonates can be prepared.