36637-93-1

Upstream product

• 35350-43-7 bis(o-nitrophenyl) diselenide 
• 7719-09-7 thionyl chloride 
• 36637-98-6 bis-(2-nitro-benzeneselenenyl)-sulfane 
• 67-66-3 chloroform 
• 7782-50-5 chlorine 
• 859322-89-7 bis-(2-nitro-phenyl)-triselenide 
• 51694-22-5 ortho-nitrophenyl selenocyanate 
• 56790-58-0 2-nitro-benzeneselenenyl bromide 
• 365-33-3 2-nitrobenzenediazonium tetrafluoroborate 
• 88-74-4 2-nitro-aniline 

Downstream Products

• 71747-44-9 (6R)-3-methyl-7t-[(2-nitro-phenylselanyl)-amino]-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester 
• 73150-42-2 (6R)-3-acetoxymethyl-7t-[(2-nitro-phenylselanyl)-amino]-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 73150-43-3 6β-[(2-nitro-phenylselanyl)-amino]-penicillanic acid 2-(4-bromo-phenyl)-2-oxo-ethyl ester 
• 58228-22-1 C₈H₁₀NO₅PSe₂ 
• 1402691-98-8 C₄₁H₄₇N₄O₂Se⁽¹⁺⁾ 
• 71747-47-2 (6R)-3-acetoxymethyl-7c-methoxy-7t-[(2-nitro-phenylselanyl)-amino]-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 73150-44-4 (R)-3-acetoxymethyl-7-(2-nitro-phenylselanylimino)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 71805-36-2 6α-methoxy-6β-[(2-nitro-phenylselanyl)-amino]-penicillanic acid 2-(4-bromo-phenyl)-2-oxo-ethyl ester 
• 73150-45-5 6-(2-nitro-phenylselanylimino)-penicillanic acid 2-(4-bromo-phenyl)-2-oxo-ethyl ester 
• 71747-46-1 (6R)-7c-methoxy-3-methyl-7t-[(2-nitro-phenylselanyl)-amino]-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester 
• 71747-45-0 (R)-3-methyl-7-(2-nitro-phenylselanylimino)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester 
• 36637-98-6 bis-(2-nitro-benzeneselenenyl)-sulfane 

Relevant academic research and scientific papers

Sensitive near-infrared fluorescent probes for thiols based on Se-N bond cleavage: Imaging in living cells and tissues

Cy-NiSe and Cy-TfSe were designed and synthesized as sensitive near-infrared (NIR) fluorescent probes for detecting thiols on the basis of Se-N bond cleavage both in cells and in tissues. Since a donor-excited photoinduced electron transfer (d-PET) process occurs between the modulator and the fluorophore, Cy-NiSe and Cy-TfSe have weak fluorescence. On titration with glutathione, the free dye exhibits significant fluorescence enhancement. The two probes are sensitive and selective for thiols over other relevant biological species. They can function rapidly at pH 7.4, and their emission lies in the NIR region. Confocal imaging confirms that Cy-NiSe and Cy-TfSe can be used for detecting thiols in living cells and tissues. Turn-on fluorescent probes Cy-NiSe and Cy-TfSe, which show weak fluorescence due to donor-excited photoinduced electron transfer, release near-infrared fluorescent dye Cy7-MeAm on cleavage of the Se-N bond by thiols. Thus, they can be used for real-time imaging of thiols such as glutathione in living cells and tissue (see figure). Copyright

A fast-response, highly sensitive and specific organoselenium fluorescent probe for thiols and its application in bioimaging

A novel organoselenium fluorescent probe (Rh-Se-2), which features a high signal-to-noise ratio (up to 170-fold), fast response (5 min) and excellent immunity to interferences, was designed, synthesized and applied to bioimaging.