3664-90-2

Basic information

• Product Name: (3alpha,5beta)-3-hydroxycholane-24-hydrazide
• CAS NO: 3664-90-2
• Molecular Formula: C₂₄H₄₂N₂O₂
• Molecular Weight: 390.6025
• Mol File: 3664-90-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 552.5°C at 760 mmHg
• Flash Point: 287.9°C
• Density: 1.067g/cm³
• Vapor Pressure: 1.66E-14mmHg at 25°C
• Refractive Index: 1.533
• CAS DataBase Reference: (3alpha,5beta)-3-hydroxycholane-24-hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: (3alpha,5beta)-3-hydroxycholane-24-hydrazide(3664-90-2)
• EPA Substance Registry System: (3alpha,5beta)-3-hydroxycholane-24-hydrazide(3664-90-2)

Safety Data

• Hazardous Substances Data: 3664-90-2(Hazardous Substances Data)

Usage

General Description

The chemical (3alpha,5beta)-3-hydroxycholane-24-hydrazide, also known as hydralazine, is a medication used to treat high blood pressure. It works by relaxing blood vessels and decreasing the resistance in the arteries, which helps lower blood pressure and improve blood flow. Hydralazine is typically used in combination with other medications to achieve the best results. It is available in oral form and is typically taken two to four times a day. Common side effects can include headache, dizziness, and a fast heartbeat, while more serious side effects can include lupus-like symptoms and blood disorders. Patients should consult with a healthcare professional before using hydralazine to discuss the potential risks and benefits of the medication.

Upstream product

• 434-13-9 Lithocholic acid 
• 1249-75-8 methyl lithocholate 

Downstream Products

• 151416-39-6 3α-hydroxy-5β-cholan-24-benzylidene-hydrazide 
• 151416-41-0 3α-hydroxy-5β-cholan-24-(p-methylbenzylidene)-hydrazide 
• 151416-40-9 3α-hydroxy-5β-cholan-24-(p-methoxybenzylidene)-hydrazide 

Relevant articles and documents

Microwave-assisted synthesis of a novel steroid-derived Schiff base chemosensor for detection of Al3+ in aqueous media

A novel steroid-derived Schiff base chemosensor, N′-(2-hydroxybenzylidene)-3α-hydroxy-cholanhydrazide (LA), has been designed and prepared via microwave irradiation. The sensor LA showed highly selective fluorescent sensing for Al3+ with a low detection limit of 34 nM in the pH range from 6.05 to 9.32 in ethanol/water (1:2, v/v) solution. The binding stoichiometry between LA and Al3+ was determined as 1:1 by Job’s plot and further verified with 1H NMR studies. Under a UV lamp, the fluorescence color changes could be easily detected by the naked eye. In addition, the sensor LA has been applied in detection of Al3+ in real water samples.

Synthesis of C-24 β-Lactams of Bile Acids

Methyl 3α-hydroxy-5β-cholan-24-oate III and methyl 3α,12α-dihydroxy-5β-cholan-24-oate IV were converted into the respective hydrazides V and VI by reaction with hydrazine.These hydrazides were reacted with aryl aldehyde VII to give the corresponding 24-ar