36640-44-5Relevant academic research and scientific papers
Synthesis of new pyrazole derivatives via multicomponent reaction and evaluation of their antimicrobial and antioxidant activities
Viveka, Shivapura,Dinesha,Madhu, Leelavathi Narayana,Nagaraja, Gundibasappa Karikannar
, p. 1547 - 1555 (2015)
Abstract This work describes a facile synthesis and characterization of a new series of pyrazole containing pyrimidine, 1,4-dihydropyridine, and imidazole derivatives using substituted 4-formylpyrazole as a key intermediate via multicomponent reaction seq
Phenyl pyrazole compound, pharmaceutical composition and preparation method and application of phenyl pyrazole compound
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Paragraph 0252-0255; 0259-0261, (2020/02/19)
The invention discloses a phenyl pyrazole compound, a pharmaceutical composition and a preparation method and application of the phenyl pyrazole compound. The phenyl pyrazole compound shown in a formula I or a formula II can be used for preparing drugs fo
One pot synthesis of thiazolo[2,3-b]dihydropyrimidinone possessing pyrazole moiety and evaluation of their anti-inflammatory and antimicrobial activities
Viveka, Shivapura,Dinesha,Nagaraja, Gundibasappa Karikannar,Shama, Prasanna,Basavarajaswamy, Guru,Rao, K. Poornachandra,Yanjarappa Sreenivasa, Marikunte
, p. 171 - 185 (2018/04/17)
A series of pyrazole integrated thiazolo[2,3-b]dihydropyrimidinone derivatives were synthesized as dual anti-inflammatory and antimicrobial agents. Among the compounds studied, 3-fluoro-4-methylphenyl analogues (3a, 3e, and 3i) are considered to be promising leads for novel anti-inflammatory agents compared with the standard drug. The superior antimicrobial property of the compounds 3a, 3b, and 3d indicates that 3-(3,4-dichlorophenyl)-1-phenyl-1H-pyrazole substitution is a favourable site for high activity. Molecular docking studies were carried out in order to predict the hypothetical binding mode of these compounds to the COX-2 isoenzyme. The results of the present study suggest that 1,3-diaryl pyrazole substitution on thiazolo[2,3-b]dihydropyrimidinone derivatives might potentially constitute a novel class of anti-inflammatory agents with antimicrobial property and could be an interesting approach for the design of new selective COX-2 inhibitory agents.
Synthesis, docking, in vitro and in vivo antidiabetic activity of pyrazole-based 2,4-thiazolidinedione derivatives as PPAR-γ modulators
Naim, Mohd. Javed,Alam, Ozair,Alam, Md. Jahangir,Shaquiquzzaman, Mohammad,Alam, Md. Mumtaz,Naidu, Vegi Ganga Modi
, (2018/02/12)
The design, synthesis, structure–activity relationship, and biological activity of 2,4-thiazolidinedione derivatives as peroxisome proliferator-activated receptor-γ (PPAR-γ) modulators for antidiabetic activity are reported. Fifteen 2,4-thiazolidinedione
