36640-50-3Relevant academic research and scientific papers
Design, synthesis and biological evaluation of novel 1,3-diarylpyrazoles as cyclooxygenase inhibitors, antiplatelet and anticancer agents
Inceler, Nazan,Ozkan, Yesim,Turan, Nilufer Nermin,Kahraman, Deniz Cansen,Cetin-Atalay, Rengul,Baytas, Sultan Nacak
, p. 795 - 811 (2018)
With the aim of achieving new compounds possessing both anti-inflammatory and antiplatelet activities, we synthesized (E)-3-[3-(pyridin-3/4-yl)-1-(phenyl/sulfonylmethylphenyl)-1H-pyrazol-4-yl]acrylamides, and evaluated their COX-1 and COX-2 inhibitory and
Microwave-Assisted Synthesis and Antimicrobial Activity of Novel Pyrazole–Indanone Hybrid Analogs
Sundergoud, Sh.,Swamy, M. Kumara,Veerasomaiah, P.,Venkatesh, N.
, p. 1635 - 1639 (2020/10/22)
Abstract: A simple and efficient microwave-assisted protocol has been developed for the synthetic of a series of novel pyrazole–indanone hybrid analogs. The target compounds have been synthesized by the Claisen–Schmidt condensation of different 1,3-diphenyl-1H-pyrazole-4-carbaldehydes with 2,3-dihydro-1H-inden-1-one in the presence of potassium hydroxide. The compounds were characterized by IR, 1H and 13C NMR, and mass spectra and were found to exhibit potent antimicrobial activity in vitro.
Synthesis, docking, in vitro and in vivo antidiabetic activity of pyrazole-based 2,4-thiazolidinedione derivatives as PPAR-γ modulators
Naim, Mohd. Javed,Alam, Ozair,Alam, Md. Jahangir,Shaquiquzzaman, Mohammad,Alam, Md. Mumtaz,Naidu, Vegi Ganga Modi
, (2018/02/12)
The design, synthesis, structure–activity relationship, and biological activity of 2,4-thiazolidinedione derivatives as peroxisome proliferator-activated receptor-γ (PPAR-γ) modulators for antidiabetic activity are reported. Fifteen 2,4-thiazolidinedione
Synthesis and biological evaluation of novel pyrazolic chalcone derivatives as novel hepatocellular carcinoma therapeutics
Hawash, Mohammed M.A.,Kahraman, Deniz Cansen,Eren, Fikriye,Cetin Atalay, Rengul,Baytas, Sultan Nacak
, p. 12 - 26 (2017/02/23)
Despite having the second highest mortality associated with cancer, currently Sorafenib is the only FDA-approved chemotherapeutic agent available for liver cancer patients which can only improve survival for few months. In this study, various pyrazolic ch
Synthesis, cytotoxicity, and molecular properties prediction of novel 1,3-diarylpyrazole derivatives
Baytas, Sultan Nacak,Inceler, Nazan,Yilmaz, Akin
, p. 4893 - 4908 (2013/09/23)
A novel combinatorial library of ester and amide derivatives of 1,3-diarylpyrazoles was designed and synthesized. Anticancer activities of these compounds were assessed against MCF7, MDA-MB-231, HeLa, Raji, and HL60 human cancer cells by MTT assay. Out of
Pyrazol-4-acetic acid compounds
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, (2008/06/13)
Pyrazol-4-acetic acid compounds, such as substituted pyrazol-4-acetic acid, its esters, amides, nitriles and their pharamaceutically acceptable salts and method for the preparation of these compounds are disclosed. The novel compounds are useful analgesics, anti-inflammatory, and antipyretics.
