36640-62-7

Usage

Uses

Used in Pharmaceutical Applications:
(1-(4-chlorophenyl)-3-phenyl-1H-pyrazol-4-yl)methanol is used as a potential therapeutic agent for the treatment of various diseases due to its diverse biological activities and structural features. Its potential as a medicinal compound makes it a candidate for further research and development in the field of medicinal chemistry and drug discovery.

Upstream product

• 98-86-2 acetophenone 
• 36640-48-9 1-(4-chlorophenyl)-3-phenyl-1Hpyrazole-4-carboxaldehyde 
• 1073-70-7 4-chlorophenylhydrazine hydrochloride 
• 143851-18-7 (E)-1-(4-chlorophenyl)-2-(1-phenylethylidene)hydrazine 

Relevant academic research and scientific papers

Synthesis, pharmacological activities and molecular docking studies of pyrazolyltriazoles as anti-bacterial and anti-inflammatory agents

A series of novel pyrazolyl alcohols (5a-h), pyrazolyl azides (6a-h), and pyrazolyltriazoles (8a-h, 10a-p and 12a-l) were prepared and evaluated for their bioactivity (anti-bacterial and anti-inflammatory) profile. The compound 5c displayed the potent anti-bacterial activity against Micrococcus luteus (MIC 3.9 and MBC 7.81 μg/mL). In vitro anti-inflammatory activity data denoted that compound 8b is effective among the tested compounds against IL-6 (IC50 6.23 μM). Docking analysis of compounds 5f, 8a-b, 8e-f and 8h displayed high binding energies for the compounds 8a-b and 8h towards TNF-α dimer (2AZ5 protein) and IL-6 (1ALU protein). In vivo anti-inflammatory activity of compounds 8b and 8h with respect to LPS induced mice model indicated that compound 8h showed significant reduction in TNF-α.

Pyrazol-4-acetic acid compounds

Pyrazol-4-acetic acid compounds, such as substituted pyrazol-4-acetic acid, its esters, amides, nitriles and their pharamaceutically acceptable salts and method for the preparation of these compounds are disclosed. The novel compounds are useful analgesics, anti-inflammatory, and antipyretics.