366487-68-5

Upstream product

• 71908-03-7 (2SR,3RS)-2-methyl-1,3-diphenyl-3-hydroxypropan-1-one 
• 100-52-7 benzaldehyde 
• 93-55-0 1-phenyl-propan-1-one 

Relevant academic research and scientific papers

Efficient preparation of 1,3-Diol derivatives with three contiguous stereocenters by an enantioselective direct aldol-tishchenko reaction

1,3-Diol derivatives with three contiguous stereocenters were efficiently prepared by an enantioselective direct aldol-Tishchenko reaction catalyzed by dilithium 3,3-diphenylbinaphtholate. The reactions of acyclic ketones as aldol donors gave 1,2-syn-1,3-

Synthesis of Yb complexes with amino-acid-armed ligands for direct asymmetric tandem aldol reduction reactions

A synthetic route to a series of C2-symmetric chiral ligands armed with selectively protected amino acids have been developed with the aim to study the potential of the corresponding Yb(III) complexes for enantioselective direct aldol reactions

Chiral ytterbium complex-catalyzed direct asymmetric aldol-tishchenko reaction: Synthesis of anti-1,3-diols

The asymmetric aldol-Tishchenko reaction of aromatic aldehydes with aliphatic and aromatic ketones has been developed as an efficient strategy for the synthesis of anti-1,3-diols in good yield with high diastereo-control and good levels of enantiose-lectivity. This domino-type reaction is catalyzed by a chiral ytterbium complex that promotes both the aldol reaction through enolization of the carbon yl compound and the Evans-Tishchenko reduction of the aldol intermediate. The stereochemistry of the resulting diols is also investigated and finally proved by using CD techniques.

Direct asymmetric aldol-Tishchenko reaction of aliphatic ketones catalyzed by syn-aminoalcohol-Yb(III) complexes

The asymmetric direct aldol condensation of aldehydes with ethyl- and propylketones is catalyzed by syn-α-aminoalcohol-Yb(OTf)3 complexes, yielding the anti-1,3-diol monoesters with high diastereocontrol and good enantioselectivity. Three adjac