36685-66-2

Basic information

• Product Name: (2E)-3-(3,4-dimethoxyphenyl)-1-(4-methoxyphenyl)prop-2-en-1-one
• Synonyms: 2-Propen-1-one, 3-(3,4-dimethoxyphenyl)-1-(4-methoxyphenyl)-; 2-propen-1-one, 3-(3,4-dimethoxyphenyl)-1-(4-methoxyphenyl)-, (2E)-; Chalcone, 3,4,4'-trimethoxy-
• CAS NO: 36685-66-2
• Molecular Formula: C₁₈H₁₈O₄
• Molecular Weight: 298.3331
• Mol File: 36685-66-2.mol

Chemical Properties

• Boiling Point: 467°C at 760 mmHg
• Flash Point: 206.7°C
• Density: 1.139g/cm³
• Vapor Pressure: 6.75E-09mmHg at 25°C
• Refractive Index: 1.58
• CAS DataBase Reference: (2E)-3-(3,4-dimethoxyphenyl)-1-(4-methoxyphenyl)prop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-3-(3,4-dimethoxyphenyl)-1-(4-methoxyphenyl)prop-2-en-1-one(36685-66-2)
• EPA Substance Registry System: (2E)-3-(3,4-dimethoxyphenyl)-1-(4-methoxyphenyl)prop-2-en-1-one(36685-66-2)

Safety Data

• Hazardous Substances Data: 36685-66-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
(2E)-3-(3,4-dimethoxyphenyl)-1-(4-methoxyphenyl)prop-2-en-1-one is used as an intermediate in the synthesis of pharmaceuticals for its ability to form various organic compounds.
Used in Organic Chemistry:
(2E)-3-(3,4-dimethoxyphenyl)-1-(4-methoxyphenyl)prop-2-en-1-one is used as a versatile compound in organic chemistry for its potential applications in the synthesis of various organic compounds.
Used in Biochemical Research:
(2E)-3-(3,4-dimethoxyphenyl)-1-(4-methoxyphenyl)prop-2-en-1-one is used in biochemical research for its potential biological activities, including anti-inflammatory and antioxidant properties.

Upstream product

• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 100-06-1 1-(4-methoxyphenyl)ethanone 

Downstream Products

• 1450996-16-3 4-(5-(3,4-dimethoxyphenyl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide 
• 1464148-61-5 (4-(3,4-dimethoxyphenyl)-1H-pyrrol-3-yl)(4-methoxyphenyl)methanone 
• 489399-30-6 4-(3,4-dimethoxyphenyl)-6-(4-methoxyphenyl)-3,4-dihydropyrimidine-2(1H)-thione 
• 1032469-68-3 1-thiocarbamoyl-3-(4-methoxyphenyl)-5-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole 
• 80816-91-7 1-(3,4-dimethoxyphenyl)-3-(4-methoxybenzoyl)propanol 
• 179930-48-4 5-(3,4-Dimethoxy-phenyl)-3-(4-ethoxy-phenyl)-7-(4-methoxy-phenyl)-2-thioxo-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one 
• 179930-49-5 5-(3,4-Dimethoxy-phenyl)-3,7-bis-(4-methoxy-phenyl)-2-thioxo-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one 
• 179930-59-7 2-Amino-4-(3,4-dimethoxy-phenyl)-6-(4-methoxy-phenyl)-nicotinamide 
• 175550-31-9 5-(3,4-Dimethoxy-phenyl)-3-(4-methoxy-phenyl)-1-phenyl-4,5-dihydro-1H-pyrazole 
• 179930-57-5 2-Amino-4-(3,4-dimethoxy-phenyl)-6-(4-methoxy-phenyl)-nicotinonitrile 
• 84801-75-2 (4S,5R)-5-(3,4-Dimethoxy-phenyl)-4-(4-methoxy-benzoyl)-1-(4-methoxy-phenyl)-4,5-dihydro-1H-pyrazole-3-carboxylic acid ethyl ester 

Relevant articles and documents

Targeting microbial resistance: Synthesis, antibacterial evaluation, DNA binding and modeling study of new chalcone-based dithiocarbamate derivatives

New dithiocarbamate chalcone-based derivatives were synthesized, their structures were elucidated using different spectroscopic techniques. They were subjected to antimicrobial screening against selected Gram negative bacteria focusing on microbial resistance. Bacterial resistance was targeted via phosphoethanolamine transferase enzyme. Most of the synthesized compounds showed equal or higher activity to colistin standard. Compound 24 proved to be the most active candidate with MIC of 8 μg/ml against both Ps12 and K4 and MBC of 32 μg/ml against Ps12 and 16 μg/ml against K4 Molecular docking study showed that 20, 22, 24 and 25 had good binding affinity with active site residues via Thr280. DNA macromolecule was further targeted. Compounds 28 and 34 were recorded to have better DNA binding than doxurubucin with IC50 of 27.48 and 30.97 μg/ml respectively, suggesting that it could have a role in their higher antibacterial effect. Their docking into DNA has shown a clear intercalation matching with antibacterial data. Pharmacokinetics parameters of active compounds showed that they have better absorption through GIT.