367-19-1

Upstream product

• 367-27-1 2,4-difluorophenol 

Downstream Products

• 864543-80-6 5-bromo-2,4-bis-(2,4-difluorophenoxy)pyrimidine 
• 927663-36-3 2.4-bis-(2.4-difluoro-phenoxy)-pyrimidine-5-carboxylic acid ((R)-2-methanesulfonyl-1-methyl-ethyl)-amide 
• 927663-35-2 2,4-bis-(2,4-difluoro-phenoxy)-pyrimidine-5-carboxylic acid ((R)-1-methyl-2-methylsulfanyl-ethyl)-amide 
• 927663-34-1 2,4-bis-(2,4-difluoro-phenoxy)-pyrimidine-5-carboxylic acid 
• 380621-82-9 1-(allyloxy)-2,4-difluorbenzol 

Relevant academic research and scientific papers

Selective ortho-hydroxylation-defluorination of 2-fluorophenolates with a Bis(μ-oxo)dicopper(III) species

The bis(μ-oxo)dicopper(III) species [CuIII 2(μ-O)2(m-XYLMeAN)]2+ (1) promotes the electrophilic ortho-hydroxylation-defluorination of 2-fluorophenolates to give the corresponding catechols, a reaction that is not accomplishable with a (η2:η2-O2) dicopper(II) complex. Isotopic labeling studies show that the incoming oxygen atom originates from the bis(μ-oxo) unit. Ortho-hydroxylation-defluorination occurs selectively in intramolecular competition with other ortho-substituents such as chlorine or bromine. O in, F out: [CuIII2(μ-O) 2(m-XYLMeAN)]2+ is a bis(μ-oxo)dicopper(III) species and promotes the electrophilic ortho-hydroxylation-defluorination of 2-fluorophenolates to give the corresponding catechols. Isotopic labeling shows that the incoming oxygen atom originates from the bis(μ-oxo) unit. Ortho-hydroxylation-defluorination occurs selectively in intramolecular competition with other ortho-substituents such as chlorine or bromine.