927663-35-2Relevant academic research and scientific papers
3-Amino-pyrazolo[3,4-d]pyrimidines as p38α kinase inhibitors: Design and development to a highly selective lead
Soth, Michael,Abbot, Sarah,Abubakari, Allassan,Arora, Nidhi,Arzeno, Humberto,Billedeau, Roland,Dewdney, Nolan,Durkin, Kieran,Frauchiger, Sandra,Ghate, Manjiri,Goldstein, David M.,Hill, Ronald J.,Kuglstatter, Andreas,Li, Fujun,Loe, Brad,McCaleb, Kristen,McIntosh, Joel,Papp, Eva,Park, Jaehyeon,Stahl, Martin,Sung, Man-Ling,Suttman, Rebecca,Swinney, David C.,Weller, Paul,Wong, Brian,Zecic, Hasim,Gabriel, Tobias
, p. 3452 - 3456 (2011)
Learnings from previous Roche p38-selective inhibitors were applied to a new fragment hit, which was optimized to a potent, exquisitely selective preclinical lead with a good pharmacokinetic profile.
p38 MAP kinase inhibitors and methods for using the same
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Page/Page column 53, (2008/06/13)
Compounds of formula 1a or 1b: wherein A, W, X, Y, R1, R2, R3 and R4 are as defined herein. Also disclosed are methods of making the compounds and methods of using the compounds for treatment of p38 MAP kinase-mediated diseases.
