864543-80-6

Basic information

• Product Name: Pyrimidine, 5-bromo-2,4-bis(2,4-difluorophenoxy)-
• CAS NO: 864543-80-6
• Molecular Formula: C16H7BrF4N2O2
• Molecular Weight: 415.141
• Mol File: 864543-80-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Pyrimidine, 5-bromo-2,4-bis(2,4-difluorophenoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrimidine, 5-bromo-2,4-bis(2,4-difluorophenoxy)-(864543-80-6)
• EPA Substance Registry System: Pyrimidine, 5-bromo-2,4-bis(2,4-difluorophenoxy)-(864543-80-6)

Safety Data

• Hazardous Substances Data: 864543-80-6(Hazardous Substances Data)

Upstream product

• 36082-50-5 2,4-dichloro-5-bromopyrimidine 
• 367-27-1 2,4-difluorophenol 
• 367-19-1 sodium 2,4-difluorophenoxide 

Downstream Products

• 864543-81-7 1-[2,4-bis-(2,4-difluorophenoxy)pyrimidin-5-yl]-3-methylbutan-1-one 
• 927663-35-2 2,4-bis-(2,4-difluoro-phenoxy)-pyrimidine-5-carboxylic acid ((R)-1-methyl-2-methylsulfanyl-ethyl)-amide 
• 927663-36-3 2.4-bis-(2.4-difluoro-phenoxy)-pyrimidine-5-carboxylic acid ((R)-2-methanesulfonyl-1-methyl-ethyl)-amide 
• 927663-34-1 2,4-bis-(2,4-difluoro-phenoxy)-pyrimidine-5-carboxylic acid 

Relevant articles and documents

3-Amino-pyrazolo[3,4-d]pyrimidines as p38α kinase inhibitors: Design and development to a highly selective lead

Learnings from previous Roche p38-selective inhibitors were applied to a new fragment hit, which was optimized to a potent, exquisitely selective preclinical lead with a good pharmacokinetic profile.

p38 MAP kinase inhibitors and methods for using the same

Compounds of formula 1a or 1b: wherein A, W, X, Y, R1, R2, R3 and R4 are as defined herein. Also disclosed are methods of making the compounds and methods of using the compounds for treatment of p38 MAP kinase-mediated diseases.

FUSED PYRAZOLE AS p38 MAP KINASE INHIBITORS

Fused pyrazoles effective as p38 MAP kinase inhibitors, methods of making the compounds, and methods of using the compounds for treatment of p38 MAP kinase-mediated diseases.