1007205-38-0

Upstream product

• 769167-55-7 (S)-2-cyclopentyloxycarbonyl-amino-8-nonenoic acid 
• 769167-58-0 (1S,2R)-1-{[(2S,4S)-4-(4-bromo-benzenesulfonyloxy)-1-((S)-2-cyclopentyloxycarbonylamino-oct-7-enoyl)pyrrolidine-2-carbonyl]-amino}-2-vinylcyclopropanecarboxylic acid methyl ester 
• 881683-80-3 ethyl (2S)-N-Boc-2-amino-5-oxo-non-8-enoate 
• 879623-40-2 18-(4-bromobenzenesulfonyloxy)-14-cyclopentyloxycarbonylamino-2,15-dioxo-3,16-diaza-tricyclo-[14.3.0.0(4,6)]nonadec-7-ene-4-carboxylic acid methyl ester 
• 367258-59-1 4-(4-bromobenzenesulfonyloxy)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 
• 801282-60-0 C₂₃H₂₉BrN₂O₈S 
• 1098199-68-8 C₁₈H₂₁BrN₂O₆S*ClH 
• 873223-12-2 14-cyclopentyloxycarbonylamino-18-[2-(2-isopropylaminothiazol-4-yl)-7-methoxyquinolin-4-yloxy]-2,15-dioxo-3,16-diaza-tricyclo[14.3.0.0(4,6)]nonadec-7-ene-4-carboxylic acid methyl ester 
• 881683-81-4 ethyl (S)-((tert-butoxycarbonyl)amino)non-8-enoate 
• 1338649-97-0 C₂HF₃O₂*C₁₁H₂₁NO₂ 
• 1051392-89-2 (S)-2-cyclopentyloxycarboxycarbonylamino-non-8-enoic acid ethyl ester 
• 74844-91-0 1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate 
• 144978-35-8 (S)-ethyl N-tert-butoxycarbonylpyroglutamate 

Relevant academic research and scientific papers

A concise synthesis of the HCV protease inhibitor BILN 2061 and its P3 modified analogs

A concise synthesis of BILN 2061 was achieved through more efficient installation of P2 4-quinoline moiety via SN2 displacement of the β-OBs group located on the 4-hydroxyl proline intermediate, which was prepared from 4-α-hydroxyl proline analog via Mitsunobu reaction with inversion of stereochemistry. In addition, a short and practical synthesis for P3 unit is also described herein. Final assembly of four fragments for BILN 2061 was achieved with an overall yield of 58% in 4 steps from P1 to 15a. Furthermore several analogs of BILN 2061 (WX-1-WX-5) containing modifications on P3 unit were synthesized successfully using the same synthetic route as described for the parent inhibitor BILN 2061. Copyright