879623-40-2Relevant academic research and scientific papers
Making the family portrait complete: Synthesis of Electron Withdrawing Group activated Hoveyda-Grubbs catalysts bearing sulfone and ketone functionalities
Arlt, Dieter,Bieniek, Micha?,Bujok, Robert,Grela, Karol,Kajetanowicz, Anna,Milewski, Mariusz
, (2020/05/06)
Synthesis of five Electron Withdrawing Group (EWG) activated Hoveyda-Grubbs’ catalysts containing thioperfluoroalkyl, sulfone and ketone functions is reported. The catalytic activity of these catalysts was well correlated with the σp values of
A concise synthesis of the HCV protease inhibitor BILN 2061 and its P3 modified analogs
Liu, Dejun,Dong, Jingchao,Yin, Yunxing,Ma, Rujian,Shi, Yifeng,Wu, Hao,Chen, Shuhui,Li, Ge
, p. 1489 - 1502 (2011/11/01)
A concise synthesis of BILN 2061 was achieved through more efficient installation of P2 4-quinoline moiety via SN2 displacement of the β-OBs group located on the 4-hydroxyl proline intermediate, which was prepared from 4-α-hydroxyl proline analog via Mitsunobu reaction with inversion of stereochemistry. In addition, a short and practical synthesis for P3 unit is also described herein. Final assembly of four fragments for BILN 2061 was achieved with an overall yield of 58% in 4 steps from P1 to 15a. Furthermore several analogs of BILN 2061 (WX-1-WX-5) containing modifications on P3 unit were synthesized successfully using the same synthetic route as described for the parent inhibitor BILN 2061. Copyright
Rational design and evaluation of upgraded Grubbs/Hoveyda olefin metathesis catalysts: Polyfunctional benzylidene ethers on the test bench
Bieniek, Michaa,Samojaowicz, Cezary,Sashuk, Volodymyr,Bujok, Robert,Sledz, Pawe,Lugan, Noel,Lavigne, Guy,Arlt, Dieter,Grela, Karol
scheme or table, p. 4144 - 4158 (2011/10/03)
The series of upgraded Grubbs/Hoveyda second-generation catalysts (H 2IMes)(Cl)2Ru=C(H)(C6H4OR) (E2 (71% yield), R = CH(Me)(C(O)OMe); M2 (58% yield), R = CH(C(O)OMe)2; Kme2 (88% yield), R = CH2/
