367281-02-5

Usage

Uses

2-Cyclohexylpyrrolidine was used to study the enzymic catalysis and homogeneous catalysis.

InChI:InChI=1/C10H19N/c1-2-5-9(6-3-1)10-7-4-8-11-10/h9-11H,1-8H2

Upstream product

• 3042-22-6 2-phenyl-1H-pyrrole 
• 152711-33-6 2-cyclohexyl-1-pyrroline 
• 635-90-5 1-phenylpyrrole 
• 1006-64-0 2-(phenyl)pyrrolidine 
• 2163-44-2 diethyl 2-cyclohexylmalonate 
• 626-62-0 Cyclohexyl iodide 
• 931-50-0 cyclohexylmagnesium bromide 
• 123-75-1 pyrrolidine 
• 110-82-7 cyclohexane 

Downstream Products

• 1232403-88-1 C₁₀H₁₉N 
• 1232406-43-7 C₁₀H₁₉N 
• 558478-73-2 (S)-1-amino-3-(2-cyclohexylpyrrolidin-1-yl) propan-2-ol 
• 558478-72-1 (R)-1-azido-3-(2-cyclohexylpyrrolidin-1-yl) propan-2-ol 

Relevant academic research and scientific papers

Bcl-2 INHIBITORS

Disclosed herein is a compound of Formula (I) for inhibiting Bcl-2 and treating disease associated with undesirable bcl-2 activity (Bcl-2 related diseases), a method of using the compounds disclosed herein for treating dysregulated apoptotic diseases including cancers and treating autoimmune disease, and a pharmaceutical composition comprising the same.

DIRECT C-H AMINATION AND AZA-ANNULATION

In some aspects, the present disclosure provides methods of aminating an aromatic compound comprising reacting an aminating agent with an aromatic compound in the presence of a rhodium catalyst. In some embodiments, the methods may comprise aminating an aromatic compound which contains multiple different functional groups. The methods described herein may also be used to create bicyclic system comprising reacting an intramolecular aminating agent with an aromatic ring to obtain a second ring containing a nitrogen atom. In another aspect, the methods described herein may also be used to create a cyclic aliphatic cyclic/poly cyclic amine system comprising a reacting an intramolecular aminating agent by insertion into a C(sp3)-H bond.

Tf2O-Promoted Intramolecular Schmidt Reaction of the ω-Azido Carboxylic Acids

A designed Tf2O-promoted intramolecular Schmidt reaction of 2-substituted ω-azido carboxylic acids was demonstrated. Tf2O was used as an activation reagent for the carboxylic acid, and ω-azido anhydride was in situ generated, releasing a molecular TfOH, which acted as an acid promoter for the Schmidt process. A series of 2-substituted pyrrolidines was produced and acetylated for better purification. The strategy was also efficient for conversion of a 4-substituted ω-azido carboxylic acid to the tricyclic lactam.

Enantioselective synthesis of amines by combining photoredox and enzymatic catalysis in a cyclic reaction network

Visible light-driven reduction of imines to enantioenriched amines in aqueous solution is demonstrated for the first time. Excitation of a new water-soluble variant of the widely used [Ir(ppy)3] (ppy = 2-phenylpyridine) photosensitizer in the p

Catalyst-Controlled Diastereoselective Synthesis of Cyclic Amines via C-H Functionalization

Reliable regio- and stereochemical techniques applicable to nonactivated aliphatic systems remain largely elusive due to the challenges of discriminating between multiple, relatively strong sp3 C-H bonds whose chemical behavior often differ onl

Synthesis of 2-substituted pyrrolidines from nitriles

A novel and synthetically facile production of 2-substituted pyrrolidines from commercially available nitriles is reported herein. This methodology is operationally simple, and only requires the use of an extraction and a single chromatographic purificati

Functionalization of nitrogen and oxygen containing heterocycles by mercury photosensitized dehydrodimerizations

Nitrogen and oxygen containing heterocycles can be functionalized by mercury photosensitization.