36741-17-0

Basic information

• Product Name: 4,5-bis(4-bromophenyl)-2-phenyl-1H-imidazole
• Synonyms: 4,5-bis(4-bromophenyl)-2-phenyl-1H-imidazole
• CAS NO: 36741-17-0
• Molecular Formula: C₂₁H₁₄Br₂N₂
• Molecular Weight: 454.15726
• Mol File: 36741-17-0.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4,5-bis(4-bromophenyl)-2-phenyl-1H-imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-bis(4-bromophenyl)-2-phenyl-1H-imidazole(36741-17-0)
• EPA Substance Registry System: 4,5-bis(4-bromophenyl)-2-phenyl-1H-imidazole(36741-17-0)

Safety Data

• Hazardous Substances Data: 36741-17-0(Hazardous Substances Data)

Upstream product

• 2789-89-1 1,2-bis(4-bromophenyl)acetylene 
• 100-51-6 benzyl alcohol 
• 5405-28-7 1,2-di(4-bromophenyl)-1,2-dibromoethane 
• 35578-47-3 4,4'-dibromobenzil 
• 100-52-7 benzaldehyde 

Downstream Products

• 186406-41-7 2-Phenyl-4,5-bis-(4-phenylethynyl-phenyl)-1H-imidazole 

Relevant articles and documents

TMSOTf-catalyzed synthesis of trisubstituted imidazoles using hexamethyldisilazane as a nitrogen source under neat and microwave irradiation conditions

In the process of drug discovery and development, an efficient and expedient synthetic method for imidazole-based small molecules from commercially available and cheap starting materials has great significance. Herein, we developed a TMSOTf-catalyzed synthesis of trisubstituted imidazoles through the reaction of 1,2-diketones and aldehydes using hexamethyldisilazane as a nitrogen source under microwave heating and solvent-free conditions. The chemical structures of representative trisubstituted imidazoles were confirmed using X-ray single-crystal diffraction analysis. This synthetic method has several advantages including the involvement of mild Lewis acid, being metal- and additive-free, wide substrate scope with good to excellent yields and short reaction time. Furthermore, we demonstrate the application of the methodology in the synthesis of biologically active imidazole-based drugs.

One-Pot, Two-Step Metal and Acid-Free Synthesis of Trisubstituted Imidazole Derivatives via Oxidation of Internal Alkynes Using an Iodine/DMSO System

A one-pot, two-step, simple, efficient and eco-friendly oxidation of internal alkynes as a key step towards the synthesis of 2,4,5-trisubstituted imidazoles, using an inexpensive I2/DMSO system, has been reported. This metal and acid-free synthesis proceeded smoothly to furnish a variety of synthetically useful trisubstituted imidazoles in moderate to excellent yields. In an effort to demonstrate the potential future applications of this system, a double oxidation study was undertaken and the desired trisubstituted imidazoles obtained in good to moderate yields.