367487-78-3Relevant academic research and scientific papers
NOVEL METHOD
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, (2008/06/13)
There is provided a method of prevention of adhesions, eg surgical adhesions, which comprises using a vitamin D compound.
Enantioselective synthesis of a key "A-ring" intermediate for the preparation of 1α-fluoro vitamin D3 analogues
Giuffredi, Guy,Bobbio, Carla,Gouverneur, Veronique
, p. 5361 - 5364 (2007/10/03)
1α-Fluoro A-ring dienol 2, a useful building block for the preparation of fluorinated vitamin D3 analogues, was synthesized in eight steps from 4-{[tert-butyldimethylsilyl]oxy}-cyclohexanone. The most distinctive synthetic development to emerge from this new synthesis is an unprecedented substrate-controlled diastereoselective fluorodesilylation of an advanced dienylsilane intermediate. This is the first enantioselective route to compound 2 relying on the use of an electrophilic fluorinating reagent.
Efficient synthesis of 1α-fluoro A-ring phosphine oxide, a useful building block for vitamin D analogues, from (S)-carvone via a highly selective palladium-catalyzed isomerization of dieneoxide to dieneol
Kabat,Garofalo,Daniewski,Hutchings,Liu,Okabe,Radinov,Zhou
, p. 6141 - 6150 (2007/10/03)
The 1α-fluoro A-ring phosphine oxide 1, a useful building block for fluorinated vitamin D analogues, was synthesized from (S)-carvone in 13 synthetic steps, and only five isolations, in 22% overall yield. In the key synthetic step, a highly selective palladium-catalyzed isomerization of dieneoxide 18 to dieneol 20 was achieved using an appropriately selected fluorinated alcohol as a catalytic proton source.
