36772-98-2

Usage

Preparation

Preparation by bromination of resacetophenone in acetic acid.

Upstream product

• 89-84-9 2',4'-dihydroxy-4-acetophenone 
• 7402-45-1 α,α,α-tribromoacetophenone 
• 56923-41-2 bis-(5-acetyl-2,4-dihydroxy-phenyl)-sulfide 
• 855938-10-2 bis-(5-acetyl-3-bromo-2,4-dihydroxy-phenyl)-sulfide 
• 108-46-3 recorcinol 

Downstream Products

• 672938-16-8 7-acetoxy-6,8-dibromo-4-methyl-3-phenyl-coumarin 
• 126521-72-0 2,4-dibromo-6-ethylresorcinol 
• 873403-43-1 6,8-dibromo-7-hydroxy-4-methyl-3-phenyl-coumarin 
• 1351163-30-8 C₁₅H₉Br₂ClO₃ 
• 1351163-28-4 C₁₈H₁₆Br₂O₆ 
• 1351163-29-5 C₁₅H₁₀Br₂O₄ 
• 1351163-32-0 C₁₆H₁₂Br₂O₄ 
• 1351163-31-9 C₁₇H₁₄Br₂O₅ 
• 1448640-50-3 5-(3,5-dibromo-2,4-dihydroxybenzoyl)-2-oxo-2H-1-(pyridin-2-yl)pyridine-3-carbonitrile 
• 1448640-51-4 2-(3,5-dibromo-2,4-dihydroxybenzoyl)pyrido[1,2-a]benzimidazole-4-carbonitrile 
• 1448640-52-5 6-[(3,5-dibromo-2,4-dihydroxyphenyl)carbonyl]-1,3-dimethyl-1H,2H,3H,4H-pyrido[2,3-d]pyrimidine-2,4-dione 

Relevant academic research and scientific papers

Benzonate derivatives of acetophenone as potent α-glucosidase inhibitors: synthesis, structure–activity relationship and mechanism

In this article, 23 compounds (6 and 7a–7v) were prepared and evaluated for their in vitro α-glucosidase inhibitory activity. The compounds 7d, 7f, 7i, 7n, 7o, 7r, 7s, 7u, and 7v displayed the α-glucosidase inhibition activity with IC50 values ranging from 1.68 to 7.88 μM. Among all tested compounds, 7u was found to be the most efficient, being 32-fold more active than the standard drug acarbose, which significantly attenuated postprandial blood glucose in mice. In addition, the compound 7u also induced the fluorescence quenching and conformational changes of enzyme, by forming α-glucosidase–7u complex in a mixed inhibition type. The thermodynamic constants recognised the interaction between 7u and α-glucosidase and was an enthalpy-driven spontaneous exothermic reaction. The synchronous fluorescence and CD spectra also indicate that the compound 7u changed the enzyme conformation. The findings identify the binding interactions between new ligands and α-glucosidase and reveal the compound 7u as a potent α-glucosidase inhibitor.

Acetophenone compound and preparation method thereof, and application of acetophenone compound to preparation of medicines used for treating cancer

The invention discloses an acetophenone compound and a preparation method thereof, and application of the acetophenone compound to preparation of medicines used for treating cancer. The invention especially discloses the acetophenone compound and a prepar

The synthesis and synergistic antifungal effects of chalcones against drug resistant Candida albicans

To identify effective and low toxicity synergistic antifungal compounds, 24 derivatives of chalcone were synthesized to restore the effectiveness of fluconazole against fluconazole-resistant Candida albicans. The minimal inhibitory concentration (MIC80) and the fractional inhibitory concentration index (FICI) of the antifungal synergist fluconazole were measured against fluconazole-resistant Candida albicans. This was done via methods established by the clinical and laboratory standards institute (CLSI). Of the synthesized compounds, 2′-hydroxy-4′-methoxychalcone (8) exhibited the most potent in vitro (FICI = 0.007) effects. The structure activity relationship of the compounds are then discussed.

Studies on the chemical behavior of the novel 6,8-dibromo-7- hydroxychromone-3-carboxaldehyde towards some carbon nucleophilic reagents

A novel 6,8-dibromo-7-hydroxychromone-3-carboxaldehyde (4) was prepared by the Vilsemier-Haack formylation of 3,5-dibromo-2,4-dihydroxy acetophenone (3). The chemical reactivity of carboxaldehyde 4 was studied towards some carbon nucleophiles as cyclic and acyclic active methylene nucleophiles and also 1,3-C,N- and 1,3-C,C-binucleophiles as a route to achieve ring transformation to produce a variety of heterocyclic systems. Structures of the newly synthesized products have been deduced on the basis of elemental analysis and spectral data.

Fibrinogen receptor antagonists and their use

This invention relates to novel fused bicyclic compounds of the general formula (I): wherein the symbols are defined herein, to pharmaceutical compositions containing the compounds, processes for preparing the compounds, and to methods of using the compounds, alone or in combination with other therapeutic agents. The compounds are antagonists of the platelet glycoprotein IIb/IIIa fibrinogen receptor complex, and are therefore useful for the inhibition of platelet aggregation, and for the treatment of thrombotic diseases and other diseases.

FIBRINOGEN RECEPTOR ANTAGONISTS AND THEIR USE

This invention relates to novel fused bicyclic compounds of the general formula (I): wherein the symbols are defined herein, to pharmaceutical compositions containing the compounds, processes for preparing the compounds, and to methods of using the compounds, alone or in combination with other therapeutic agents. The compounds are antagonists of the platelet glycoprotein IIb/IIIa fibrinogen receptor complex, and are therefore useful for the inhibition of platelet aggregation, and for the treatment of thrombotic diseases and other diseases.

Pyridinium bromochromate: A new and efficient reagent for bromination of hydroxy aromatics

Pyridinium bromochromate (PBC) has been used as an efficient and selective nuclear brominating agent for bromination of various substituted hydroxy-acetophenones, aldehydes and phenols.

Total syntheses of (2S)-antafumicins A and B.

To clarify the absolute configurations of antafumicins A and B, which are antifungal substances from Aspergillus niger NH-401, the total synthesis of (2S)-antafumicins was accomplished by starting from (S)-malic acid in 12 steps. Based upon the physicochemical data of the synthetic samples, the absolute configurations of naturally occurring antafumicins A and B were determined as (2R,4S)- and (2R,4R)-4-(3-acetyl-2,6-dihydroxyphenyl)-2-methoxy-4-butanolide, respectively.