36776-32-6

Basic information

• Product Name: Benzonitrile, 4-(hydroxyacetyl)-
• CAS NO: 36776-32-6
• Molecular Formula: C9H7NO2
• Molecular Weight: 161.16
• Mol File: 36776-32-6.mol
• Article Data: 18

Chemical Properties

• CAS DataBase Reference: Benzonitrile, 4-(hydroxyacetyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzonitrile, 4-(hydroxyacetyl)-(36776-32-6)
• EPA Substance Registry System: Benzonitrile, 4-(hydroxyacetyl)-(36776-32-6)

Safety Data

• Hazardous Substances Data: 36776-32-6(Hazardous Substances Data)

Usage

General Description

Benzonitrile, 4-(hydroxyacetyl)- is a chemical compound with the molecular formula C9H7NO2. It is a derivative of benzonitrile, which is a colorless liquid used in the production of herbicides, perfumes, and pharmaceuticals. The 4-(hydroxyacetyl)- group attached to the benzonitrile molecule adds a hydroxyacetyl functional group, making it useful as a building block in organic synthesis. Benzonitrile, 4-(hydroxyacetyl)- can undergo various chemical reactions such as esterification, alkylation, and oxidation, making it versatile for use in different types of chemical processes. It is important to handle this compound with care as it can be toxic and harmful if not used properly.

Upstream product

• 101219-69-6 4-(1-hydroxyethyl)benzonitrile 
• 74087-85-7 3,3-dimethyldioxirane 
• 20099-89-2 4-Cyanophenacyl bromide 
• 67-56-1 methanol 
• 182058-00-0 4-(1-((Trimethylsilyl)oxy)vinyl)benzonitrile 
• 50-00-0 formaldehyd 
• 105-07-7 4-cyanobenzaldehyde 
• 3435-51-6 4-ethenylbenzonitrile 
• 57508-48-2 carbethoxyacetamidine hydrochloride 
• 3058-39-7 4-iodobenzonitrile 
• 1379462-83-5 α-acetoxy-4-cyanoacetophenone 
• 1443-80-7 4-cyanophenyl methyl ketone 

Downstream Products

• 1355159-05-5 tert-butyl 2-(1-(4-cyanophenyl)-2-hydroxyethylamino)acetate 
• 1355159-15-7 N-[1-(4-cyanophenyl)-2-hydroxyethyl]-D-alanine 
• 1355159-06-6 tert-butyl 2-(2-(tert-butyldimethylsilyloxy)-1-(4-cyanophenyl)ethylamino)acetate 
• 1355254-61-3 tert-butyl N-(1-{4-[(Z)-amino(hydroxyimino)methyl]phenyl}-2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)-D-alaninate 
• 1355159-16-8 tert-butyl N-[2-{[tert-butyl(dimethyl)silyl]oxy}-1-(4-cyanophenyl)ethyl]-D-alaninate 
• 1355159-98-6 tert-butyl N-[2-{[tert-butyl(dimethyl)silyl]oxy}-1-(4-{5-[2'-methyl-2-(trifluoromethyl)biphenyl-4-yl]-1,2,4-oxadiazol-3-yl}phenyl)ethyl]-D-alaninate 
• 1355159-99-7 tert-butyl N-[2-hydroxy-1-(4-{5-[2'-methyl-2-(trifluoromethyl)biphenyl-4-yl]-1,2,4-oxadiazol-3-yl}phenyl)ethyl]-D-alaninate 
• 1044250-06-7 4-(2-(3-oxo-1,3-dihydroisobenzofuran-1-yl)acetyl)benzonitrile 
• 173727-98-5 (R)-1-(4-cyanophenyl)-1,2-ethanediol 

Relevant articles and documents

Palladium-Catalyzed [5 + 2] Annulation of Vinylethylene Carbonates with Barbiturate-Derived Alkenes

A palladium/XantPhos-catalyzed [5 + 2] annulation of VECs with electron-deficient alkenes having an isolated carbon-carbon double bond has been developed to afford spirobarbiturate-tetrahydrooxepines. This study provides an expedient assembly of biologically interesting spirobarbiturate-tetrahydrooxepines. The easy scalability and versatile transformability of the reaction products were also exhibited.

Spiro[indene-1,4′-oxa-zolidinones] Synthesis via Rh(III)-Catalyzed Coupling of 4-Phenyl-1,3-oxazol-2(3 H)-ones with Alkynes: A Redox-Neutral Approach

Transition-metal-catalyzed C-H activation synthesis of heterocyclic spiro[4,4]nonanes has persistently witnessed the use of additional stoichiometric transition-metal oxidant when employing C=C bond as the spiro ring closure site. Herein, we have addressed the issue by reporting a redox-neutral strategy for spiro[indene-1,4′-oxa-zolidinones] synthesis via Rh(III)-catalyzed coupling of 4-phenyl-1,3-oxazol-2(3H)-ones with alkynes. The synthesis features a broad substrate scope and high regiospecificity.

Divergent synthesis of N-heterocycles by Pd-catalyzed controllable cyclization of vinylethylene carbonates

Here, we report a palladium-catalyzed controllable cyclization of vinyl ethylene carbonates that proceeds through formal migration [2+3] and [5+2] cycloadditions, respectively, under mild conditions. The transformation described here affords a series of synthetically versatile 5,7-membered N-heterocycles which are found in natural products and pharmaceuticals with biological and medicinal properties.