367911-45-3Relevant academic research and scientific papers
Synthesis of novel halogenated cryptolepine analogues
Gouni, Srinivas Reddy,Carrington,Wright
, p. 171 - 175 (2007/10/03)
Cryptolepine (5-N-methyl-10-H-indolo[3,2-b]quinoline) is an indoloquinoline alkaloid present in the roots of Cryptolepis Sanguinolenta. In its hydrochloride form the alkaloid presents a number of bioactivities. The alkaloid also has cytotoxic properties t
Synthesis and evaluation of cryptolepine analogues for their potential as new antimalarial agents
Wright,Addae-Kyereme,Breen,Brown,Cox,Croft,G?k?ek,Kendrick,Phillips,Pollet
, p. 3187 - 3194 (2007/10/03)
The indoloquinoline alkaloid cryptolepine 1 has potent in vitro antiplasmodial activity, but it is also a DNA intercalator with cytotoxic properties. We have shown that the antiplasmodial mechanism of 1 is likely to be due, at least in part, to a chloroqu
