367925-77-7Relevant academic research and scientific papers
Synthesis of oxazolidinones by a solid-phase/activation cycloelimination (sp/ace) methodology
Ten Holte, Peter,Van Esseveldt, Bart C. J.,Thijs, Lambertus,Zwanenburg, Binne
, p. 2965 - 2969 (2007/10/03)
A versatile method for the solid-phase synthesis of oxazolidinones is described. An appropriate 1,2-diol is attached to immobilized sulfonyl chloride, resulting in the selective activation of one of the alcohol functions. The subsequent reaction of the ot
Oxazolidinone combinatorial libraries, compositions and methods of preparation
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, (2008/06/13)
Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.
