368-88-7

Basic information

• Product Name: 4-FLUOROBENZENESULFONIC ACID
• Synonyms: 4-FLUOROBENZENESULFONIC ACID;4-fluorobenzenesulphonic acid;Benzene-1-fluoro-4-sulfonic acid;NSC43021;p-Fluorobenzenesulfonic acid;p-Fluorophenylsulfonic acid
• CAS NO: 368-88-7
• Molecular Formula: C₆H₅FO₃S
• Molecular Weight: 176.17
• EINECS: 206-714-0
• Mol File: 368-88-7.mol
• Article Data: 14

Chemical Properties

• Melting Point: 87℃
• Appearance: /
• Density: 1.513
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: -0.66±0.50(Predicted)
• Water Solubility: 434.9g/L(21.3 oC)
• CAS DataBase Reference: 4-FLUOROBENZENESULFONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FLUOROBENZENESULFONIC ACID(368-88-7)
• EPA Substance Registry System: 4-FLUOROBENZENESULFONIC ACID(368-88-7)

Safety Data

• Hazardous Substances Data: 368-88-7(Hazardous Substances Data)

Usage

Uses

4-Fluorobenzenesulphonic Acid is used as a reactant in the synthesis of HCV inhibitors based on thiazolone scaffold.

InChI:InChI=1/C6H5FO3S/c7-5-1-3-6(4-2-5)11(8,9)10/h1-4H,(H,8,9,10)

Upstream product

• 462-06-6 fluorobenzene 
• 349-88-2 4-Fluorobenzenesulfonyl chloride 
• 371-42-6 4-Fluorothiophenol 
• 657-47-6 Fluorbenzol-3-sulfonsaeure 
• 405-31-2 bis(4-fluorophenyl)disulfide 
• 125568-47-0 4-fluorobenzenesulfinic acid ethyl ester 
• 7664-93-9 sulfuric acid 
• 305-80-6 4-diazobenzenesulfonic acid 
• 352-34-1 4-fluoro-1-iodobenzene 

Downstream Products

• 462-06-6 fluorobenzene 
• 657-47-6 Fluorbenzol-3-sulfonsaeure 
• 35300-35-7 2-fluorobenzenesulfonic acid 
• 2070902-77-9 trifluoromethyl 4-fluorobenzene-1-sulfonate 
• 216983-39-0 1-((4-fluorophenyl)sulfonyl)piperidin-4-one 
• 2797-28-6 lithium tetrakis(pentafluorophenyl)borate 
• 1637586-78-7 4-((1-((4-fluorophenyl)sulfonyl)piperidin-4-yl)oxy)aniline 
• 1637586-82-3 1-ethyl-3-(4-((1-((4-fluorophenyl)sulfonyl)piperidin-4-yl)oxy)phenyl)urea 
• 1637586-76-5 C₁₇H₁₇FN₂O₅S 
• 371-42-6 4-Fluorothiophenol 

Relevant articles and documents

Complementary Site-Selective Sulfonylation of Aromatic Amines by Superacid Activation

Under superacidic conditions, aniline and indole derivatives are sulfonylated at low temperature with easy-to-access arenesulfonic acids or arenesulfonyl hydrazides. By modification of the functional-group directing effect through protonation, this method allows nonclassical site functionalization by overcoming the innate regioselectivity of electrophilic aromatic substitution. This superacid-mediated sulfonylation of arenes is complementary to existing methods and can be applied, through protection by protonation, to the late-stage site-selective functionalization of natural alkaloids and active pharmaceutical ingredients.

Sustainable access to sulfonic acids from halides and thiourea dioxide with air

A sustainable and mild one-step strategy is explored for the synthesis of aryl and alkyl sulfonic acids using a facile combination of halides and sulfur dioxide surrogates under air. The cheap industrial material thiourea dioxide was employed as an eco-friendly and easy-handling sulfur dioxide surrogate, while air was used as a green oxidant. Both aryl and alkyl sulfonic acids were obtained under transition metal-catalyzed or transition metal-free conditions. Mechanistic studies demonstrated that sulfinate was involved as an intermediate in this transformation. Notably, this protocol has been applied to the late-stage sulfonation of the drugs naproxen, isoxepac and ibuprofen.

Preparation method of vonoprazan fumarate and intermediate thereof

The invention discloses a preparation method of vonoprazan fumarate. The method comprises the steps that R1) a compound of formula I is subjected to sulfonation to obtain a compound of formula II; R2)the compound of the formula II is dissolved in a solven