36808-17-0

Upstream product

• 1450-72-2 5-methyl-2-hydroxyacetophenone 
• 100-39-0 benzyl bromide 
• 100-44-7 benzyl chloride 

Downstream Products

• 36803-96-0 2-(benzyloxy)-5-methylphenyl acetate 
• 96754-79-9 1-(2-benzyloxy-5-methylphenyl)-3-(6-benzodioxan-1,4-yl)-2,3-epoxypropan-1-one 
• 96754-79-9 (2-Benzyloxy-5-methyl-phenyl)-[(2S,3R)-3-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-oxiranyl]-methanone 
• 909413-75-8 1-(2-benzyloxy-5-methyl-phenyl)-3-(4-pyridin-2-yl-piperazin-1-yl)-propan-1-one oxime 
• 471242-48-5 1-(2-benzyloxy-5-methyl-phenyl)-2-bromo-ethanone 
• 96755-20-3 1-(2-benzyloxy-5-methylphenyl)-3-(6-benzodioxan-1,4-yl)propenone 
• 87487-59-0 (E)-3-Benzofuran-2-yl-1-(2-benzyloxy-5-methyl-phenyl)-propenone 
• 87487-53-4 (E)-1-(2-Benzyloxy-5-methyl-phenyl)-3-(3,6-dimethyl-benzofuran-2-yl)-propenone 

Relevant academic research and scientific papers

N-(PYRIDIN-2-YLSULFONYL)CYCLOPROPANECARBOXAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF A CFTR MEDIATED DISEASE

The invention relates to heterocyclic compounds of the formula (I), in which all of the variables are as defined in the specification; capable of modulating the activity of CFTR. The invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including Cystic fibrosis and related disorders.

Design, synthesis and biological evaluation of novel ring-opened cromakalim analogues with relaxant effects on vascular and respiratory smooth muscles and as stimulators of elastin synthesis

Two new series of ring-opened analogues of cromakalim bearing sulfonylurea moieties (series A: with N-unmethylated sulfonylureas, series B: with N-methylated sulfonylureas) were synthesized and tested as relaxants of vascular and respiratory smooth muscle

Synthesis of Spirofurooxindoles via Phenyliodine(III) Bis(trifluoroacetate) (PIFA)-Mediated Cascade Oxidative C?O and C?C Bond Formation

Upon treatment with solely a hypervalent iodine reagent of phenyliodine(III) bis(trifluoroacetate) (PIFA), 3-(2-hydroxyphenyl)-3-oxo-N-phenyl propanamides and a series of its derivatives were conveniently converted to a class of undocumented spirofurooxindoles under mild conditions. Control experiments provided evidence that this spirocyclization process encompassed a cascade oxidative reactions involving the formation of a C?O bond prior to that of C?C bond. (Figure presented.).

Selective bromination of acetophenone derivatives with bromine in methanol

Acetophenone derivatives are selectively brominated in the acetyl side-chain with bromine in methanol at 0-5° by manipulating the electron density in the aromatic ring in good yield.