3682-28-8 Usage
Uses
Used in Pharmaceutical Industry:
(4-Phenyl-4H-1,2,4-triazol-3-yl)thio]acetic acid is used as a potential therapeutic agent for its anticancer and antitumor properties. It targets the growth of cancer cells, making it a promising candidate for the development of novel cancer treatments.
Used in Anticancer Applications:
In the field of oncology, (4-Phenyl-4H-1,2,4-triazol-3-yl)thio]acetic acid is utilized as an inhibitor of Thymidylate synthase, which plays a vital role in DNA biosynthesis and replication. By inhibiting this enzyme, the compound can potentially disrupt the proliferation of cancer cells, offering a new avenue for cancer treatment.
Used in Antimicrobial Applications:
(4-Phenyl-4H-1,2,4-triazol-3-yl)thio]acetic acid is also being studied for its potential use in treating various microbial infections and diseases. Its ability to target essential cellular processes may provide a new approach to combating drug-resistant pathogens and improving patient outcomes in the context of infectious diseases.
Further research is necessary to fully understand the potential applications and limitations of (4-Phenyl-4H-1,2,4-triazol-3-yl)thio]acetic acid in medicine and pharmacology, as well as to optimize its use in various therapeutic settings.
Check Digit Verification of cas no
The CAS Registry Mumber 3682-28-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,6,8 and 2 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 3682-28:
(6*3)+(5*6)+(4*8)+(3*2)+(2*2)+(1*8)=98
98 % 10 = 8
So 3682-28-8 is a valid CAS Registry Number.
InChI:InChI=1/C10H9N3O2S/c14-9(15)6-16-10-12-11-7-13(10)8-4-2-1-3-5-8/h1-5,7H,6H2,(H,14,15)
3682-28-8Relevant academic research and scientific papers
Synthesis and antimicrobial and pharmacological properties of new thiosemicarbazide and 1,2,4-triazole derivatives
Popiolek, Lukasz,Dobosz, Maria,Chodkowska, Anna,Jagiello-Wojtowicz, Ewa,Kosikowska, Urszula,Malm, Anna,Mazur, Liliana,Rzaczynska, Zofia
, p. 339 - 346 (2011/06/19)
Reaction of 4-phenyl-4H-1,2,4-triazole-3-thione with ethyl bromoacetate has led to the formation of ethyl [(4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetate 1, the structure of which was confirmed by X-ray analysis. In the next reaction with 80% hydrazide hydrate, appropriate hydrazide 2 was obtained, which in reaction with isothiocyanates was converted to new acyl derivatives of thiosemicarbazides 3a-3h. The cyclization of these compounds in alkaline media has led to formation of new derivatives of 5-{[(4-phenyl-4H-1,2,4-triazole-3-yl) sulfanyl]methyl}-4H-1,2,4-triazole-3(2H)-thiones 4a-4g, 4j. The structure of the compounds was confirmed by elementary analysis and IR, 1H-NMR, 13C-NMR, and MS spectra. Compounds 3a-3h and 4a-4g were screened for their antimicrobial activities, and the influence of the compounds 4a, 4b, and 4e-4g on the central nervous system of mice in behavioral tests was examined.
