84210-48-0

Upstream product

• 5373-72-8 4-phenyl-Δ²-1,2,4-triazoline-5-thione 
• 105-36-2 ethyl bromoacetate 

Downstream Products

• 18333-83-0 2-[(4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]-N-[(2-hydroxyphenyl)methylidene]acetohydrazide 
• 18333-84-1 2-[(4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]-N-[(4-methoxyphenyl)methylidene]acetohydrazide 
• 6264-24-0 1-{[(4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetyl}-4-phenylthiosemicarbazide 
• 59909-04-5 [(4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetohydrazide 
• 3682-28-8 [(4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetic acid 
• 1306760-99-5 4-carboxymethyl-5-{[(4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}-4H-1,2,4-triazole-3(2H)-thione 
• 1289425-26-8 4-(4-bromophenyl)-5-{[(4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}-4H-1,2,4-triazole-3(2H)-thione 
• 1289425-24-6 4-cyclohexyl-5-{[(4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}-4H-1,2,4-triazole-3(2H)-thione 
• 1289425-22-4 4-benzyl-5-{[(4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}-4H-1,2,4-triazole-3(2H)-thione 
• 1289425-20-2 5-{[(4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}-4-(4-tolyl)-4H-1,2,4-triazole-3(2H)-thione 
• 1289425-18-8 5-{[(4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}-4-(4-methoxyphenyl)-4H-1,2,4-triazole-3(2H)-thione 
• 1289425-16-6 5-{[(4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}-4-phenyl-4H-1,2,4-triazole-3(2H)-thione 
• 1289425-15-5 4-ethoxycarbonyl-1-{[(4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetyl}thiosemicarbazide 
• 1306760-89-3 4-ethoxycarbonylmethyl-1-{[(4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetyl}thiosemicarbazide 

Relevant academic research and scientific papers

Synthesis and Antimicrobial Evaluation of New Schiff Base Hydrazones Bearing 1,2,4-Triazole Moiety

This study presents the synthesis and spectral analysis of new Schiff base hydrazone derivatives. New compounds were prepared by the reaction of [(4-phenyl-5-substituted-4H-1,2,4-triazol-3-yl)sulfanyl] acetohydrazide with various aldehydes. The structures

Synthesis and antimicrobial and pharmacological properties of new thiosemicarbazide and 1,2,4-triazole derivatives

Reaction of 4-phenyl-4H-1,2,4-triazole-3-thione with ethyl bromoacetate has led to the formation of ethyl [(4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetate 1, the structure of which was confirmed by X-ray analysis. In the next reaction with 80% hydrazide hydrate, appropriate hydrazide 2 was obtained, which in reaction with isothiocyanates was converted to new acyl derivatives of thiosemicarbazides 3a-3h. The cyclization of these compounds in alkaline media has led to formation of new derivatives of 5-{[(4-phenyl-4H-1,2,4-triazole-3-yl) sulfanyl]methyl}-4H-1,2,4-triazole-3(2H)-thiones 4a-4g, 4j. The structure of the compounds was confirmed by elementary analysis and IR, 1H-NMR, 13C-NMR, and MS spectra. Compounds 3a-3h and 4a-4g were screened for their antimicrobial activities, and the influence of the compounds 4a, 4b, and 4e-4g on the central nervous system of mice in behavioral tests was examined.