36828-24-7

Upstream product

• 101118-74-5 2-(2-chloro-1-phenyl-vinyl)-benzoic acid methylamide 
• 110474-85-6 2-(2-chloro-1-phenyl-vinyl)-benzoic acid anilide 
• 100865-28-9 2-(2-chloro-1-phenyl-vinyl)-benzoic acid amide 
• 18019-56-2 3-methyl-3-phenylphthalide 
• 77077-79-3 2-Hydroxy-4-phenylisocarbostyril 
• 536-74-3 phenylacetylene 
• 613-94-5 benzoic acid hydrazide 
• 98-88-4 benzoyl chloride 
• 108-86-1 bromobenzene 
• 136918-14-4 phthalimide 
• 6637-53-2 3-hydroxy-3-phenyl-2,3-dihydro-isoindol-1-one 
• 16618-72-7 3-phenyl-1-indanone 

Downstream Products

• 84555-30-6 2-(3-diethylamino-2-hydroxypropyl)-4-phenyl-1(2H)-isoquinolone 
• 84555-26-0 2-(2,3-epoxypropyl)-4-phenyl-1(2H)-isoquinolone 
• 84555-22-6 2-(2-hydroxypropyl)-4-phenyl-1(2H)-isoquinolone 
• 78745-99-0 2-(3-hydroxypropyl)-4-phenyl-1(2H)-isoquinolone 

Relevant academic research and scientific papers

Synthesis of isoquinolones by visible-light-induced deaminative [4+2] annulation reactions

Herein a metal-free approach for the synthesis of isoquinolone derivatives by means of photoinitiated deaminative [4+2] annulation of alkynes and N-amidepyridinium salts is described. This protocol exhibits a broad scope and good functional group tolerance and regioselectivity under benign reaction conditions. Preliminary studies suggest that the critical amide radical is derived from the photocatalytic cleavage of the N-N bond of the N-amidepyridinium salt, which adds to the triple bond of the alkyne and undergoes the annulation process to afford the desired isoquinolones.

Method for preparing isoquinolin-1-ketone derivative

The invention provides a method for preparing an isoquinolin-1-ketone derivative, and relates to the method for preparing the isoquinolin-1-ketone derivative. The object of the invention is to solve the problems of cumbersome steps, low yield and environm

A chiral Br?nsted acid-catalyzed highly enantioselective Mannich-type reaction of α-diazo esters with in situ generated N -acyl ketimines

A chiral phosphoric acid-catalyzed asymmetric Mannich-type reaction of α-diazo esters with in situ generated N-acyl ketimines, derived from 3-hydroxyisoindolinones has been demonstrated in this communication. A variety of isoindolinone-based α-amino diazo esters bearing a quaternary stereogenic center were afforded in high yields (up to 99%) with excellent enantioselectivities (up to 99% ee). Furthermore, the synthetic utility of the products has been depicted by the hydrogenation of the diazo moiety of adducts.

Base-Catalysed Nitrosation of 1-Indanones - A Novel Ring Expansion Reaction

The 1-indanones 1-4, substituted in the five-membered ring, react with butyl nitrite in the presence of sodium methoxide to give exclusively the 2-hydroxyisocarbostyrils 8-11.In the absence of substituents (5-7) the reaction is accompanied by the formation of 2-hydroxyimino derivatives (22-24) which are obtained as main products.