368422-27-9 Usage
General Description
2-(methoxymethoxy)-5-(trifluoromethyl)benzoic acid, also known as TFMBA, is a chemical compound that is commonly used as a building block in organic synthesis. It appears as a white solid and is soluble in polar organic solvents. TFMBA is frequently utilized in the pharmaceutical industry as an intermediate in the synthesis of various drugs and active pharmaceutical ingredients. Its chemical structure contains a benzene ring substituted with a trifluoromethyl group at the 5 position and two methoxymethoxy groups at the 2 position, making it a versatile reagent for the production of complex organic molecules. Additionally, TFMBA has found applications in the development of various materials and agrochemical products due to its unique chemical properties.
Check Digit Verification of cas no
The CAS Registry Mumber 368422-27-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,6,8,4,2 and 2 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 368422-27:
(8*3)+(7*6)+(6*8)+(5*4)+(4*2)+(3*2)+(2*2)+(1*7)=159
159 % 10 = 9
So 368422-27-9 is a valid CAS Registry Number.
368422-27-9Relevant articles and documents
Fluorophenols and (trifluoromethyl)phenols as substrates of site-selective metalation reactions: To protect or not to protect
Marzi, Elena,Mongin, Florence,Spitaleri, Andrea,Schlosser, Manfred
, p. 2911 - 2915 (2007/10/03)
O-Methoxymethyl (MOM) protected fluorophenols can be cleanly metalated and subsequently be submitted to site-selective electrophilic substitution. The 2- and 4-isomers exhibit ambivalent reactivity: deprotonation occurs at the position adjacent to the oxygen when butyllithium is employed whereas the position adjacent to the fluorine is attacked by the superbasic mixture of butyllithium and potassium tert-butoxide (LIC-KOR). The MOM-protected (trifluoromethyl)-phenols react exclusively at oxygen-neighboring positions. The meta isomer provides another example of optional site selectivity, undergoing hydrogen/metal exchange at the 2-position with the LIC-KOR reagent and at the 6-position with sec-butyllithium. Unprotected (trifluoromethyl)phenols can also be ortho-metalated after O-deprotonation, although the products are formed in only moderate yields.
