368448-91-3

Upstream product

• 38447-05-1 (2E,4E)-methyl 5-phenylpenta-2,4-dienoate 
• 17480-69-2 (S)-N-benzyl-1-phenylethylamine 

Downstream Products

• 170726-18-8 methyl (3S)-3-amino-5-phenylpentanoate 
• 368448-92-4 methyl (2S,3S,4E,αS)-2-methyl-3-(N-benzyl-N-α-methylbenzylamino)-5-phenylpent-4-enoate 
• 158807-52-4 methyl (3S)-3-(N-tert-butoxycarbonylamino)-5-phenylpentanoate 
• 368448-99-1 (3R,4E)-3-amino-5-phenylpent-4-enoic acid 
• 368449-00-7 (2S,3S,4E)-3-amino-2-methyl-5-phenylpent-4-enoic acid 
• 368448-93-5 methyl (2S,3S)-3-amino-2-methyl-5-phenylpentanoate 
• 368448-95-7 methyl (3R,4E)-3-(N-tert-butoxycarbonylamino)-5-phenylpent-4-enoate 
• 368448-96-8 methyl (2S,3S,4E)-3-(N-tert-butoxycarbonylamino)-2-methyl-5-phenylpent-4-enoate 
• 368448-97-9 (3R,4E)-3-(N-tert-butoxycarbonylamino)-5-phenylpent-4-enoic acid 
• 368448-98-0 (2S,3S,4E)-3-(N-tert-butoxycarbonylamino)-2-methyl-5-phenylpent-4-enoic acid 
• 368448-94-6 methyl (2S,3R)-3-(N-tert-butoxycarbonylamino)-2-methyl-5-phenylpentanoate 

Relevant academic research and scientific papers

Serine-threonine protein phosphatase inhibitors derived from nodularin: Role of the 2-methyl and 3-diene groups in the Adda residue and the effect of macrocyclic conformational restraint

In order to probe the effect upon macrocycle conformation and PP1cat enzyme inhibition of structural changes to nodularin, specific replacements for the Adda residue were introduced. Two new analogues, cyclo[-(3S,E)-3-phenylethenyl-3-aminopropa