56003-06-6Relevant academic research and scientific papers
Synthesis of substituted isoquinolines via Pd-catalyzed cross-coupling approaches
Todorovic, Nick,Awuah, Emelia,Albu, Silvia,Ozimok, Cory,Capretta, Alfredo
, p. 6180 - 6183 (2012/01/03)
Palladium complexes incorporating ligands based on a 1,3,5,7-tetramethyl-2, 4,8-trioxa-6-phosphaadamantanyl scaffold were used to catalyze the arylation of ethyl cyanoacetate, malononitrile, and various ketones. The products from these reactions can be el
Discovery of 1-arylcarbonyl-6,7-dimethoxyisoquinoline derivatives as glutamine fructose-6-phosphate amidotransferase (GFAT) inhibitors
Qian, Yimin,Ahmad, Mushtaq,Chen, Shaoqing,Gillespie, Paul,Le, Nam,Mennona, Frank,Mischke, Steven,So, Sung-Sau,Wang, Hong,Burghardt Charles,Tannu, Shahid,Conde-Knape, Karin,Kochan, Jarema,Bolin, David
scheme or table, p. 6264 - 6269 (2011/11/29)
Through high throughput screening and subsequent hit identification and optimization, we synthesized a series of 1-arylcarbonyl-6,7- dimethoxyisoquinoline derivatives as the first reported potent and reversible GFAT inhibitors. SAR studies of this class o
Substituted isoquinolines
-
, (2008/06/13)
Substituted isoquinolines of the formula STR1 wherein R is lower alkoxy, n is the integer zero or 1, and A is STR2 wherein R1 is phenyl, halophenyl, lower-alkylphenyl or lower-alkoxyphenyl, and pharmaceutically acceptable acid addition salts th
