368833-44-7

Basic information

• Product Name: 4'-acetoxy-2'-fluoroacetanilide
• Synonyms: 4'-acetoxy-2'-fluoroacetanilide
• CAS NO: 368833-44-7
• Molecular Weight: 211.193
• Mol File: 368833-44-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4'-acetoxy-2'-fluoroacetanilide(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-acetoxy-2'-fluoroacetanilide(368833-44-7)
• EPA Substance Registry System: 4'-acetoxy-2'-fluoroacetanilide(368833-44-7)

Safety Data

• Hazardous Substances Data: 368833-44-7(Hazardous Substances Data)

Upstream product

• 399-95-1 4-amino-3-fluorophenol 
• 75-36-5 acetyl chloride 
• 399-31-5 N-(2-fluorophenyl)acetamide 
• 64-19-7 acetic acid 

Downstream Products

• 103842-00-8 N-(2-fluoro-4-hydroxyphenyl)acetamide 

Relevant articles and documents

Synthesis and pharmacological evaluation of piperidine (piperazine)-amide substituted derivatives as multi-target antipsychotics

We report the optimisation of a series of novel amide-piperidine (piperazine) derivatives using the multiple ligand approach with dopamine and serotonin receptors. Of the derivatives, compound 11 exhibited high affinity for the D2, 5-HT1A, and 5-HT2A receptors, but low affinity for the 5-HT2C and histamine H1 receptors and human ether-a-go-go-related gene (hERG) channels. In vivo, compound 11 reduced apomorphine-induced climbing, MK-801-induced hyperactivity and DOI-induced head twitching without observable catalepsy, even at the highest dose tested. In addition, it exhibited suppression in a CAR test. Furthermore, in a novel object recognition task, it displayed procognition properties. Therefore, compound 11 is a promising candidate multi-target antipsychotic.