368889-83-2

Upstream product

• 55163-91-2 ethyl thioglycolate sodium salt 
• 171511-22-1 4-(4-Bromo-phenylamino)-6-chloro-2-methylsulfanyl-pyrimidine-5-carbonitrile 
• 33097-13-1 4,6-dichloro-2-(methylthio)-5-pyrimidinecarbonitrile 
• 106-40-1 4-bromo-aniline 

Downstream Products

• 171511-19-6 5-Amino-4-(4-bromo-phenylamino)-2-methylsulfanyl-thieno[2,3-d]pyrimidine-6-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

A Facile Synthesis of 5H-1-Thia-3,5,6,8-tetraazaacenaphthylenes

Ethyl 5-substituted 7-(methylthio)-5H-1-thia-3,5,6,8-tetraazaacenaphthylene-2-carboxylates (5a-f) representing a new heterocyclic system were prepared by acid-catalyzed cyclocondensation of ethyl 5-amino-4-(substituted amino)-2-(methylthio)thienopyrimidine-6-carboxylates (3a-f) with triethyl orthoformate.Compounds 3 were obtained by aminolysis of 4,6-dichloro-2-(methylthio)pyrimidine-5-carbonitrile (1) affording 2 followed by base-promoted cyclization with sodium ethyl thioglycolate. - Keywords: Thienopyrimidines, 4,5-diamino- / Triethyl orthoformate / Cyclocondensation / 5H-1-Thia-3,5,6,8-tetraazaacenaphthylenes