3689-73-4

Usage

Uses

Used in Medical Applications:
Penethamate is used as an antibiotic for treating various bacterial infections. It is prescribed to combat infections caused by susceptible bacteria, providing a crucial tool in the management of such conditions.
Used in Pharmaceutical Industry:
Penethamate is used as a therapeutic agent for the treatment of bacterial infections, playing a significant role in the development of antibiotics and the pharmaceutical industry's efforts to combat bacterial diseases.
Used in Public Health:
Penethamate is used as a preventive and curative measure in public health to control and treat bacterial infections, contributing to the overall health and well-being of communities.

InChI:InChI=1/C22H31N3O4S/c1-5-24(6-2)12-13-29-21(28)18-22(3,4)30-20-17(19(27)25(18)20)23-16(26)14-15-10-8-7-9-11-15/h7-11,17-18,20H,5-6,12-14H2,1-4H3,(H,23,26)/t17-,18+,20-/m1/s1

Upstream product

• 75-07-0 acetaldehyde 
• 113-98-4 Penicillin G potassium 
• 869-24-9 2-chloro-N,N-diethylethylamine hydrochloride 
• 69-57-8 Penicillin G sodium 
• 19870-47-4 benzylpenicillin-(carbonic acid ethyl ester)-anhydride 
• 100-37-8 2-(Diethylamino)ethanol 

Downstream Products

• 808-71-9 [2S-(2α,5α,6β)]-3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]-4-thia-1-azabiscyclo[3,2,0]heptane-2-carboxylic acid 2-(diethylamino)ethyl ester monohydroiodide 
• 7778-19-0 penethacillin hydroiodide 

Relevant academic research and scientific papers

Synthesis method of penicillin hydriodate

The invention discloses a synthesis method of penicillin and hydroiodate thereof. The synthesis method of the compound penicillin as shown in the formula III comprises the following step: in a solvent, in the presence of a reducing agent, carrying out reductive amination reaction as shown in the description on a compound as shown in a formula II and acetaldehyde to obtain the compound penicillin as shown in the formula III. The method has the advantages of brand new intermediate, simple operation, high yield, high purity, and facilitation of industrial mass production.

A synthesis method of blasting cillin hydriodate

The embodiment of the invention provides a penethamate hydroiodide synthesizing method, and belongs to the technical field of chemical synthesis. The method comprises the steps that: in an organic solvent, sodium penicillin or potassium penicillin is subjected to a reaction with 2-chloro triethylamine or 2-chloro triethylamine hydrochloride, wherein a reaction temperature is 20-80 DEG C, wherein a ratio of 2-chloro triethylamine or 2-chloro triethylamine hydrochloride to sodium penicillin or potassium penicillin is 0.8-2:1; when the reaction is finished, the organic solvent and sodium chloride or potassium chloride are removed, such that free penethamate is obtained; and the free penethamate is acidified, and is subjected to a reaction with odized salt, such that penethamate hydroiodide is obtained. According to the penethamate hydroiodide synthesis method, process steps are shortened, and high-toxicity ethyl chlorformate is directly avoided, such that post-treatment cost and environment pollution are greatly reduced. Also, reaction yield can be greatly improved, and can reach 80-90%, such that cost is reduced, and process is simplified.