7778-19-0

Upstream product

• 100410-46-6 [2S-(2α,5α,6β)]-3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]-4-thia-1-azabiscyclo[3,2,0]heptane-2-carboxylic acid 2-(diethylamino)ethyl ester hydrochloride 
• 869-24-9 2-chloro-N,N-diethylethylamine hydrochloride 
• 69-57-8 Penicillin G sodium 
• 3689-73-4 penethacillin 
• 113-98-4 Penicillin G potassium 

Relevant academic research and scientific papers

Synthesis, isolation, and purification of benzylpenicillin β-diethylaminoethyl ester hydroiodide

Processes of synthesis, isolation, and purification of benzylpenicillin β-diethylaminoethyl ester hydroiodide were studied. The optimal conditions of benzylpenicillin esterification with chloroethyldiethylamine in dimetylformamide and acetonitrile were found. Processes for isolation of the target product were developed and its physicochemical properties were studied. Product stabilization conditions providing a stable pH value in solutions of benzylpenicillin β-diethylaminoethyl ester hydroiodide were found.

Synthesis method of penicillin hydriodate

The invention discloses a synthesis method of penicillin and hydroiodate thereof. The synthesis method of the compound penicillin as shown in the formula III comprises the following step: in a solvent, in the presence of a reducing agent, carrying out reductive amination reaction as shown in the description on a compound as shown in a formula II and acetaldehyde to obtain the compound penicillin as shown in the formula III. The method has the advantages of brand new intermediate, simple operation, high yield, high purity, and facilitation of industrial mass production.

Improved preparation method of penicillin hydriodate

The invention relates to the field of pharmacy, and particularly provides an improved preparation method of penicillin hydriodate, which comprises the following steps: 1) dissolving penicillin citrate with water, then adding a sodium iodide or potassium iodide solution for reaction, growing crystals, filtering, washing and drying to obtain the penicillin hydriodate. The method disclosed by the invention has the advantages of high yield, easiness in operation and small toxicity, the reaction condition is mild, the product purification, intermediate storage and impurity control are facilitated, and the penicillin hydriodate product with good stability is obtained.

A synthesis method of blasting cillin hydriodate

The embodiment of the invention provides a penethamate hydroiodide synthesizing method, and belongs to the technical field of chemical synthesis. The method comprises the steps that: in an organic solvent, sodium penicillin or potassium penicillin is subjected to a reaction with 2-chloro triethylamine or 2-chloro triethylamine hydrochloride, wherein a reaction temperature is 20-80 DEG C, wherein a ratio of 2-chloro triethylamine or 2-chloro triethylamine hydrochloride to sodium penicillin or potassium penicillin is 0.8-2:1; when the reaction is finished, the organic solvent and sodium chloride or potassium chloride are removed, such that free penethamate is obtained; and the free penethamate is acidified, and is subjected to a reaction with odized salt, such that penethamate hydroiodide is obtained. According to the penethamate hydroiodide synthesis method, process steps are shortened, and high-toxicity ethyl chlorformate is directly avoided, such that post-treatment cost and environment pollution are greatly reduced. Also, reaction yield can be greatly improved, and can reach 80-90%, such that cost is reduced, and process is simplified.