36916-18-4

Upstream product

• 10352-30-4 2,6-dichloro-4-phenylquinoline 
• 27537-93-5 6-chloro-2-hydrazino-4-phenylquinoline 
• 78-39-7 Triethyl orthoacetate 

Downstream Products

• 72882-78-1 2-(7-chloro-5-phenyl-[1,2,4]triazolo[4,3-a]quinolin-1-yl)-N,N-dimethylethan-1-amine 
• 36916-19-5 5-chloro-2-(3-methyl-4H-1,2,4-triazol-4-yl)benzophenone 
• 36916-20-8 4-(2-benzoyl-4-chlorophenyl)-5-methyl-4H-1,2,4-triazole-3-carboxaldehyde 
• 75158-63-3 C₁₇H₁₂ClN₃O 
• 57698-44-9 7-chloro-5-phenyl-s-triazolo<4,3-a>quinoline 
• 54196-60-0 7-chloro-1-methyl-5-(o-chlorophenyl)-s-triazolo[4,3-a]quinoline 
• 38150-26-4 7-chloro-1-methyl-5-phenyl-5H-[1,2,4]triazolo[4,3-a]quinolin-4-one 

Relevant academic research and scientific papers

Novel synthesis of the pharmacologically important 1-substituted-6-phenyl-4H-s-triazolo[4,3-α][1,4]benzodiazepines

Several 6-phenyl-4H-s-triazolo[4,3-α][1,4]benzodiazepines have useful biological activity both in experimental animals and in man. This manuscript describes a novel synthesis of these compounds from intermediates that do not have a pre-formed benzodiazepine ring system.

2-[3-(Phthalimidomethyl)-5-methyl-4H-1,2,4-triazol-4-yl]benzophenones

A process to make 6-phenyl-4H-s-triazolo[4,3-a][1,4]-benzodiazepines by converting 2-[3-(hydroxymethyl)-4H-1,2,4-triazol-4-yl]benzophenones to 2-[3-[(phthalimido or methanesulfonyl)methyl]-4H-1,2,4-triazol-4-yl]benzophenones and converting these compounds to the highly active 6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines useful as tranquilizers and sedatives.

Triazolyl benzophenone compounds

Intermediates of the formula IV: STR1 wherein R is selected from the group consisting of hydrogen and alkyl of 1 to 3 carbon atoms, inclusive; and wherein R2, R3, and R4 are selected from the group consisting of hydrogen, fluoro, chloro, bromo, nitro, and trifluoromethyl are produced by a multistep synthesis. The final compounds are tranquilizers and sedatives and can be used in mammals, including man, and in birds.