36934-13-1

Upstream product

• 100-52-7 benzaldehyde 
• 762-04-9 phosphonic acid diethyl ester 
• 99-09-2 3-nitro-aniline 
• 1663-55-4 diethyl [hydroxy(phenyl)methyl]phosphonate 
• 5341-44-6 N-(3-nitrobenzylidene)aniline 
• 122-52-1 triethyl phosphite 
• 31682-65-2 diethyl phosphite 
• 53378-83-9 O,O-diethyl-α-tosyloxybenzylphosphonate 

Relevant academic research and scientific papers

Calcium chloride as an efficient lewis base catalyst for the one-pot synthesis of α-aminophosphonic esters

A simple, efficient, and general method has been developed for the one-pot synthesis of α-aminophosphonic esters, under solvent-free conditions, with the use of CaCl2 as a Lewis base catalyst. The esters were obtained under mild conditions and

A simple protocol for the synthesis of α-substituted phosphonates

An efficient, easy-to-handle, and mild substitution reaction approach has been developed for the synthesis of phosphonate derivatives, which are very important in the field of industrial, agricultural, and medicinal chemistry. A large number of nucleophiles, including arylamines, alkylamines, heteroarylamines, primary amines and secondary amines, sulfides, and carbides were attempted to react with α-tosyloxyphosphonate 1. The reaction proceeded under catalyst-free and neat conditions and the corresponding phosphonates 2 were afforded in good yields.

A Green Approach to the Synthesis of α-Amino Phosphonate in Water Medium: Carbene Insertion into the N-H Bond by Cu(I) Catalyst

Synthesis of amino phosphonates is more important owing to their significant applications in the biological systems. There are few methods already known in the literature to make these molecules; however, known methods have their own disadvantages. In this regard, synthesis of different kinds of amino phosphonates have been achieved via phosphonate substituted carbene insertion into the N-H bond of aniline catalyzed by readily available copper salt under mild reaction conditions in water. In order to find an efficient catalyst for carbene insertion reaction in neat water, a large number of transition metal catalysts were screened, and we found that the [Cu(CH3CN)4]ClO4 was the best catalyst under employed reaction conditions. Using this environmentally benign methodology (copper catalyzed reaction in water), a large number of biologically important amino phosphonates have been synthesized, isolated (37 examples), and characterized using standard analytical and spectroscopic techniques.

Clean procedure for the synthesis of A-aminophosphonates catalyzed by choline-based ionic liquid

A sulfated choline-based ionic liquid [Ch-OSO3H] was prepared and used as a novel catalyst for the synthesis of α-aminophosphonates via a one-pot three-component reaction with aldehydes, amines, and triethyl phosphite/diethyl phosphite at room temperature under solvent-free conditions or in aqueous media. The reaction was completed in short times and products could be simply separated from the reaction mixture in good to excellent yields. The catalyst could be recycled and reused for several times without noticeably reducing catalytic activity.

Ultrasound mediated synthesis of α-aminophosphonates and 3,4-dihydropyrimidin-2-ones using graphene oxide as a recyclable catalyst under solvent-free conditions

Graphene oxide is utilized as an environmentally friendly and efficient catalyst for an ultrasound mediated multi-component coupling reaction that involves aldehyde, amine/ethylacetoacetate and diethyl phosphite/urea, under solvent-free conditions, leading to the bioactive α-aminophosphonates and 3,4-dihydropyrimidin-2-ones with excellent yield. This journal is

TfOH/C-catalyzed one-pot three-component synthesis of α-amino phosphonates under solvent-free conditions

The TfOH/C was readily prepared via simple absorption of triflic acid onto activated charcoal. This solid acid was used as an efficient catalyst for the synthesis of α-aminophosphonates through the Kabachnik-Fields reaction of carbonyl compound, amine and

NbCl5: An efficient catalyst for one-pot synthesis of α-aminophosphonates under solvent-free conditions

NbCl5 has been found to be a very effective catalyst for the synthesis of a variety of α-aminophosphonates through the Kabachnik-Fields reaction of carbonyl compound, amine and diethyl phosphite under solvent-free conditions. Copyright

Synthesis of α-aminophosphonates using polystyrene supported Al(OTf)3 as a heterogeneous catalyst

A mild and efficient method has been devised for the preparation of -aminophosphonates from three component condensation of an aldehyde, an amine, and diethyl phosphite in the presence of catalytic amounts of cross-linked polystyrene supported aluminium triflate (Ps-Al(OTf)3) under solvent-free conditions in good to excellent yields. The catalyst is stable (as a bench top catalyst) and can be easily recovered and reused without appreciable change in its efficiency. Taylor & Francis Group, LLC.

SO3H-functionalized ionic liquids catalyzed the synthesis of α-aminophosphonates in aqueous media

SO3H-functionalized halogen-free ionic liquids were prepared and used as efficient and recyclable catalysts for the synthesis of α-aminophosphonates at room temperature via the one-pot three-component condensation reaction in aqueous media with good yields of 80-96%. The postprocessing was simple, and the catalysts could be reused at least six times without noticeably decreasing the catalytic activity.

CeCl37H2O-catalyzed one-pot Kabachnik-Fields reaction: A green protocol for three-component synthesis of α- aminophosphonates

CeCl37H2O has been utilized as an efficient Lewis acid catalyst for the three-component coupling of aldehydes, aromatic amines, and diethylphosphite to produce α-aminophosphonates under solvent-free conditions. The advantages of this protocol are high yield, mild reaction conditions, less environmental pollution, and simple work-up procedure.