369357-33-5Relevant academic research and scientific papers
Synthesis and biological activities of novel structural analogues of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand
Suhara, Yoshitomo,Nakane, Shinji,Arai, Shunsuke,Takayama, Hiroaki,Waku, Keizo,Ishima, Yoshio,Sugiura, Takayuki
, p. 1985 - 1988 (2001)
Novel analogues of 2-arachidonoylglycerol (2-AG), an endogenous cannabinoid receptor ligand, were developed. Chemical synthesis of these analogues (2-AGA105 and 2-AGA109) was accomplished starting from 2-octyn-1-ol and diethyl malonate and employing Wittig coupling of triene phosphonate with an aldehyde intermediate in a convergent and stereoselective manner. These analogues should be useful lead compounds for the development of novel 2-AG mimetics.
Synthesis and biological evaluation of several structural analogs of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand
Suhara, Yoshitomo,Oka, Saori,Kittaka, Atsushi,Takayama, Hiroaki,Waku, Keizo,Sugiura, Takayuki
, p. 854 - 867 (2007/10/03)
2-Arachidonoylglycerol (2-AG (1)) is an endogenous ligand for the cannabinoid receptors (CB1 and CB2). There is growing evidence that 2-arachidonoylglycerol plays important physiological and pathophysiological roles in various mammalian tissues and cells,
