36939-02-3

Basic information

• Product Name: 1-phenyl-3-(pyridin-4-yl)propan-1-one
• CAS NO: 36939-02-3
• Molecular Formula: C₁₄H₁₃NO
• Molecular Weight: 211.2591
• Mol File: 36939-02-3.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 378.1°C at 760 mmHg
• Flash Point: 189.8°C
• Density: 1.103g/cm³
• Vapor Pressure: 6.44E-06mmHg at 25°C
• Refractive Index: 1.577
• CAS DataBase Reference: 1-phenyl-3-(pyridin-4-yl)propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-phenyl-3-(pyridin-4-yl)propan-1-one(36939-02-3)
• EPA Substance Registry System: 1-phenyl-3-(pyridin-4-yl)propan-1-one(36939-02-3)

Safety Data

• Hazardous Substances Data: 36939-02-3(Hazardous Substances Data)

Usage

Ketone derivative

It is a derivative of a ketone, which is a compound with a carbonyl group (C=O) bonded to two carbon atoms.

Phenyl group attachment

First carbon of the propyl chain
A phenyl group (a ring of six carbon atoms with delocalized electrons) is attached to the first carbon atom of the propyl chain (three-carbon chain).

Pyridin-4-yl group attachment

Third carbon of the propyl chain
A pyridin-4-yl group (a six-membered nitrogen-containing ring with five carbon atoms and one nitrogen atom) is attached to the third carbon atom of the propyl chain.

Chemical reactivity

The compound can participate in various chemical reactions and synthesis processes due to the presence of its functional groups (carbonyl and aromatic rings).

Potential pharmacological uses

The compound may have potential applications in the field of medicine, but further research and studies are needed to determine its specific properties and applications.

Upstream product

• 100-43-6 4-vinylpyridine 
• 5908-41-8 benzoyltrimethylsilane 
• 586-95-8 pyridine-4-methanol 
• 98-85-1 1-Phenylethanol 
• 1074-12-0 phenylglyoxal hydrate 
• 100-52-7 benzaldehyde 
• 2057-49-0 4-(3-phenylpropyl)pyridine 
• 98-86-2 acetophenone 
• 925702-34-7 N-methoxy-N-methyl-3-pyridin-4-ylpropionamide 
• 100-58-3 phenylmagnesium bromide 

Downstream Products

• 925702-36-9 2-phenyl-3-(pyridin-4-ylmethyl)quinoline-4-carboxylic acid trifluoroacetate 

Relevant articles and documents

Palladium-Catalyzed Siloxycyclopropanation of Alkenes Using Acylsilanes

Currently, catalytically transferable carbenes are limited to electron-deficient and neutral derivatives, and electron-rich carbenes bearing an alkoxy group (i.e., Fischer-type carbenes) cannot be used in catalytic cyclopropanation because of the lack of appropriate carbene precursors. We report herein that acylsilanes can serve as a source of electron-rich carbenes under palladium catalysis, enabling cyclopropanation of a range of alkenes. This reactivity profile is in sharp contrast to that of metal-free siloxycarbenes, which are unreactive toward normal alkenes. The resulting siloxycyclopropanes serve as valuable homoenolate equivalents, allowing rapid access to elaborate β-functionalized ketones.

Phosphine-free pincer-ruthenium catalyzed biofuel production: High rates, yields and turnovers of solventless alcohol alkylation

Phosphine-free pincer-ruthenium carbonyl complexes based on bis(imino)pyridine and 2,6-bis(benzimidazole-2-yl) pyridine ligands have been synthesized. For the β-alkylation of 1-phenyl ethanol with benzyl alcohol at 140 °C under solvent-free conditions, (Cy2NNN)RuCl2(CO) (0.00025 mol%) in combination with NaOH (2.5 mol%) was highly efficient (ca. 93% yield, 372?000 TON at 12?000 TO h-1). These are the highest reported values hitherto for a ruthenium based catalyst. The β-alkylation of various alcohol combinations was accomplished with ease which culminated to give 380?000 TON at 19?000 TO h-1 for the β-alkylation of 1-phenyl ethanol with 3-methoxy benzyl alcohol. DFT studies were complementary to mechanistic studies and indicate the β-hydride elimination step involving the extrusion of acetophenone to be the overall RDS. While the hydrogenation step is favored for the formation of α-alkylated ketone, the alcoholysis step is preferred for the formation of β-alkylated alcohol. The studies were extended for the upgradation of ethanol to biofuels. Among the pincer-ruthenium complexes based on bis(imino)pyridine, (Cy2NNN)RuCl2(CO) provided high productivity (335 TON at 170 TO h-1). Sterically more open pincer-ruthenium complexes such as (Bim2NNN)RuCl2(CO) based on the 2,6-bis(benzimidazole-2-yl) pyridine ligand demonstrated better reactivity and gave not only good ethanol conversion (ca. 58%) but also high turnovers (ca. 2100) with a good rate (ca. 710 TO h-1). Kinetic studies indicate first order dependence on concentration of both the catalyst and ethanol. Phosphine-free catalytic systems operating with unprecedented activity at a very low base loading to couple lower alcohols to higher alcohols of fuel and pharmaceutical importance are the salient features of this report. This journal is

Selective C(sp3)?H Aerobic Oxidation Enabled by Decatungstate Photocatalysis in Flow

A mild and selective C(sp3)?H aerobic oxidation enabled by decatungstate photocatalysis has been developed. The reaction can be significantly improved in a microflow reactor enabling the safe use of oxygen and enhanced irradiation of the reaction mixture. Our method allows for the oxidation of both activated and unactivated C?H bonds (30 examples). The ability to selectively oxidize natural scaffolds, such as (?)-ambroxide, pregnenolone acetate, (+)-sclareolide, and artemisinin, exemplifies the utility of this new method.