36943-39-2

Upstream product

• 108-98-5 thiophenol 
• 446-52-6 2-Fluorobenzaldehyde 
• 89-98-5 2-chloro-benzaldehyde 
• 1527-14-6 phenyl 2-hydroxymethylphenyl sulfide 
• 352427-08-8 tert-Butyl [({[2-(phenylsulfanyl)phenyl]methylidene}amino)oxy]peracetate 
• 6630-33-7 ortho-bromobenzaldehyde 
• 882-33-7 diphenyldisulfane 
• 88-67-5 2-Iodobenzoic acid 
• 1527-12-4 2-(phenylthio)benzoic acid 
• 459-57-4 4-fluorobenzaldehyde 
• 552-89-6 2-nitro-benzaldehyde 
• 4551-15-9 phenylthiotrimethylsilane 
• 555-16-8 4-nitrobenzaldehdye 
• 639-58-7 triphenyltin chloride 

Downstream Products

• 61205-73-0 2-Phenylthio-benzylidenanilin 
• 131327-52-1 ethyl 2-diazo-3-hydroxy-3-(2-phenylthio)phenylpropanoate 
• 127876-58-8 1-((Z)-2-Nitro-propenyl)-2-phenylsulfanyl-benzene 
• 127876-57-7 1-nitro-2-(2-(phenylthio)phenyl)ethene 
• 132121-23-4 2-chloro-(2-(2-phenylthio)phenyl)acetic acid 
• 132121-24-5 2-hydroxy-(2-(2-phenylthio)phenyl)acetic acid 
• 90133-31-6 (2-Phenylsulfanyl-phenyl)-(2,3,4-trimethyl-phenyl)-methanol 
• 118385-20-9 p-Tolylmethanol 
• 118385-19-6 p-Bromophenylmethanol 
• 90133-31-6 mesityl<2-(phenylthio)phenyl>methanol 
• 94008-87-4 1-pentadeuteriophenyl-1-(2-phenylthiophenyl)methanol 
• 52252-65-0 1-phenyl-1-(2-phenylthiophenyl)methanol 
• 59181-70-3 1-pentafluorophenyl-1-(2-phenylthiophenyl)methanol 
• 46708-52-5 N-methyl-2-(phenylthio)benzylamine 

Relevant academic research and scientific papers

Synthesis and biological activity of sulfur-containing aryl-aldehyde Schiff bases.

A series of chemically modified aryl-aldehyde Schiff bases has been synthesized and tested for their antioxidant activity and radiation protection. We observed that disulfide-containing aryl-aldehyde Schiff base 6c exhibited potent free radical scavenging

Novel β?hydroxy ketones: Synthesis, spectroscopic characterization, molecular docking, and anticancer activity studies

In this study, a series of novel β?hydroxy ketone derivatives 3a-o were designed, synthesized, and evaluated for their anticancer activity. The structure of these compounds were characterized by IR, 1H and 13C NMR, mass spectrometry and elemental analysis methods. All the synthesized compounds were screened for anticancer activity against MCF-7 and U87 cells. Among them, compound 3l was appeared to be the most potent compound on both cancer cells; and IC50 dose was determined as 145 μM for MCF-7 cells and 6,6 μM for U87 cells. DNA ladder and Annexin V apoptotic marker tests were used and as a result, 3l caused the initiation of apoptosis on U87 cells. VDAC protein expression increased dramatically after U87 glioblastoma brain cancer cells were treated with compound 3l Additionally, the molecular modeling of these compounds was studied in FLT3 receptor, Estrogen receptor, and PARP2 receptor for the treatment of Acute Myeloid Leukemia (AML), breast cancer, and Glioblastoma (GBM) respectively. Their binding motifs and drug-like properties were investigated, and the results are highlighted in the discussion. Based on the results, compound 3l may have a potential drug candidate profile that can reverse the drug resistance profile.

Cerium-photocatalyzed aerobic oxidation of benzylic alcohols to aldehydes and ketones

We have developed a cerium-photocatalyzed aerobic oxidation of primary and secondary benzylic alcohols to aldehydes and ketones using inexpensive CeCl3 7H2O as photocatalyst and air oxygen as the terminal oxidant.

Rhodium(III)-Catalyzed Aldehyde C?H Activation and Functionalization with Dioxazolones: An Entry to Imide Synthesis

A rhodium(III)-based catalytic system has been used to develop a C?H bond activation of benzaldehyde derivatives and subsequent functionalization with dioxazolones in order to afford imides. The importance of the nature of the directing group to perform selectively the aldehydic C?H bond activation has been highlighted. The scope investigation showed that this transformation could be applied to various dioxazolones and many benzaldehyde derivatives as well as an acrolein derivative. Derivatization reactions of the imide products demonstrated the synthetic utility of this rhodium-catalyzed aldehydic C?H amidation.

Chan-Lam-Type C-S Coupling Reaction by Sodium Aryl Sulfinates and Organoboron Compounds

A Chan-Lam-Type C-S coupling reaction using sodium aryl sulfinates has been developed to provide diaryl thioethers in up to 92% yields in the presence of a copper catalyst and potassium sulfite. Both electron-rich and electron-poor sodium aryl sulfinates and diverse organoboron compounds were tolerated for the synthesis of aryl and heteroaryl thioethers and dithioethers. The mechanistic study suggested that potassium sulfite was involved in the deoxygenation of sulfinate through a radical process.

Formation and Disproportionation of Xanthenols to Xanthenes and Xanthones and Their Use in Synthesis

A facile and versatile strategy employing TiCl4-mediated cyclization followed by a Cannizzaro reaction has been developed for the synthesis of various xanthene derivatives. The reaction proceeded smoothly to afford both xanthenes/xanthones or their sulfur derivatives and tolerated a wide range of electronically diverse substrates. Using this methodology, pranoprofen was synthesized in three steps in 59% overall yield from commercially available starting materials.

Stereoselective synthesis of 9-vinyl substituted unsymmetrical xanthenes and thioxanthenes

Activated 2°-allylic alcohols derived from 2-aryloxybenzaldehydes and 2-(arythio)benzaldehydes undergo intramolecular Friedel-Crafts alkylation reaction when heated with catalytic amount of a Lewis acid in 1,2-dichloroethane to provide highly E-selective 9-vinyl substituted unsymmetrical novel xanthenes and thioxanthenes in good yields.

In(OTf)3 catalyzed reductive etherification of 2-aryloxybenzaldehydes and 2-(arylthio)benzaldehydes

2-Aryloxybenzaldehydes and 2-(arylthio)benzaldehydes undergo reductive etherification in presence of 5 mol% In(OTf)3 and stoichiometric amount of Et3SiH under solvent free conditions to generate novel symmetrical dibenzyl ethers and thioethers in excellent yields. In(OTf)3 is found to be superior in terms of catalytic activity over the other metal triflates tested for the reaction. Xanthenes and thioxanthenes, as anticipated, could not be obtained under these conditions.

Direct C-S bond formation: Via C-O bond activation of phenols in a crossover Pd/Cu dual-metal catalysis system

A dual-metal catalysis system including a newly prepared nanoparticle [SiO2@organic-linker(OL)@Pd(II)] and CuI was introduced with ultra-high catalytic activity (high turnover number (TON), up to 19000) to a one-pot and odorless synthesis of unsymmetrical aryl sulfides by crossover C-S bond formation. The reaction proceeds via C-O bond activation of phenols and direct C-S bond formation in the presence of S8 as an oddorless sulfur source and aryl boronic acids under mild conditions (room temperature). The catalyst could be recycled up to five times without an obvious change in its activity.

Synthesis of new thioxanthenes by organocatalytic intramolecular Friedel–Crafts reaction

An efficient organocatalytic route has been developed to synthesize novel substituted thioxanthenes (2a–2v) starting from diaryl thioether alcohols (1a–1v) using the intramolecular Friedel–Crafts reaction. The starting materials were obtained in two stage