3695-94-1

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
(2Z)-2,3-bis(4-chlorophenyl)prop-2-enenitrile is used as a precursor for the synthesis of various pharmaceuticals and agrochemicals, contributing to the development of new drugs and pesticides.
Used in Dye and Pigment Manufacturing:
This chemical is utilized in the manufacturing of dyes and pigments, playing a role in the production of colorants for various applications.
Used in Insecticidal and Anti-Cancer Research:
(2Z)-2,3-bis(4-chlorophenyl)prop-2-enenitrile has been studied for its potential insecticidal and anti-cancer properties, indicating its possible use in developing new treatments and pest control methods.
However, it is crucial to handle this chemical with care, as it may be harmful if ingested or inhaled and can cause irritation to the skin and eyes.

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 140-53-4 p-chlorobenzyl cyanide 

Downstream Products

• 36770-81-7 2,3-bis(4-chlorophenyl)propanenitrile 
• 148515-57-5 C₁₆H₉ClN₂ 

Relevant academic research and scientific papers

Method for preparing alkenyl cyanide compounds

The invention discloses a method for preparing alkenyl cyanide compounds represented by formula II. Alkynes represented by formula I and a cyanation reagent are subjected to a reduction reaction represented by a formula shown in the description in an organic solvent under the protection of a gas at 20-100 DEG C under the action of a nickel catalyst, a reducing agent and H2O to prepare the alkenyl cyanide compounds represented by formula II. The preparation method of the invention, which adopts the cheap nickel as the catalytic system, has the advantages of simplicity in operation, mild reaction conditions, good compatibility of functional groups, wide application range of the substrate, high reaction efficiency and high yield, so the method has high application and promotion values.

A Paal-Knorr approach to 3,4-diaryl-substituted pyrroles: Facile synthesis of lamellarins O and Q

A very simple, yet efficient synthetic methodology, to obtain 3,4-diaryl-substituted pyrroles is described. The approach is based on the Knoevenagel condensation between arylacetonitriles and substituted aromatic aldehydes, followed by conjugate addition of cyanide to afford succinonitriles in excellent yields. The products thus obtained were subjected to DIBAL-H reduction, followed by cyclization under acidic conditions to produce the corresponding pyrroles in good overall yields. The utility of this protocol is exemplified by the synthesis of the marine alkaloids lamellarins O and Q.