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3-[(4-Chlorophenyl)sulfonyl]aminopropanoic acid, also known as sulindac, is a nonsteroidal anti-inflammatory drug (NSAID) characterized by its ability to relieve pain and reduce inflammation. It operates through the inhibition of prostaglandin production, which are chemicals responsible for pain and swelling sensations in the body.
Used in Pharmaceutical Industry:
Sulindac is used as an analgesic and anti-inflammatory agent for the treatment of various conditions characterized by pain and inflammation. It is particularly effective in managing osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis due to its ability to alleviate symptoms associated with these diseases.
Used in Cancer Prevention Research:
Sulindac is also utilized in research studies exploring its potential to prevent certain types of cancer, such as colon, breast, and lung cancer. Its chemopreventive properties are being investigated to understand its impact on reducing the risk of developing these malignancies.
However, it is important to note that sulindac can have side effects, including gastrointestinal issues and an increased risk of cardiovascular events. Therefore, its use should be approached with caution and under the supervision of a healthcare professional to ensure safe and effective treatment.

36974-65-9

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36974-65-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 36974-65-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,6,9,7 and 4 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 36974-65:
(7*3)+(6*6)+(5*9)+(4*7)+(3*4)+(2*6)+(1*5)=159
159 % 10 = 9
So 36974-65-9 is a valid CAS Registry Number.
InChI:InChI=1/C9H10ClNO4S/c10-7-1-3-8(4-2-7)16(14,15)11-6-5-9(12)13/h1-4,11H,5-6H2,(H,12,13)/p-1

36974-65-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-[(4-chlorophenyl)sulfonylamino]propanoic acid

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:36974-65-9 SDS

36974-65-9Downstream Products

36974-65-9Relevant academic research and scientific papers

In silico identification, design and synthesis of novel piperazine-based antiviral agents targeting the hepatitis C virus helicase

Bassetto, Marcella,Leyssen, Pieter,Neyts, Johan,Yerukhimovich, Mark M.,Frick, David N.,Courtney-Smith, Matthew,Brancale, Andrea

supporting information, p. 1115 - 1131 (2016/11/09)

A structure-based virtual screening of commercial compounds was carried out on the HCV NS3 helicase structure, with the aim to identify novel inhibitors of HCV replication. Among a selection of 13 commercial structures, one compound was found to inhibit the subgenomic HCV replicon in the low micromolar range. Different series of new piperazine-based analogues were designed and synthesised, and among them, several novel structures exhibited antiviral activity in the HCV replicon assay. Some of the new compounds were also found to inhibit HCV NS3 helicase function in?vitro, and one directly bound NS3 with a dissociation constant of 570?±?270?nM.

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