36978-18-4Relevant academic research and scientific papers
Regioselective Wacker-Type Oxidation of Internal Olefins in tBuOH Using Oxygen as the Sole Oxidant and tBuONO as the Organic Redox Cocatalyst
Huang, Qing,Li, Ya-Wei,Ning, Xiao-Shan,Jiang, Guo-Qing,Zhang, Xiao-Wei,Qu, Jian-Ping,Kang, Yan-Biao
supporting information, p. 965 - 969 (2020/02/15)
A regioselective Wacker-Tsuji oxidation of internal olefins in tBuOH has been developed using oxygen as the terminal oxidant and tert-butyl nitrite as the simple organic redox cocatalyst without the involvement of hazardous cocatalysts or harsh reaction conditions. A series of internal olefins bearing various functional groups can be oxidized to the corresponding substituted ketones in generally good yields with high regioselectivities.
Catalytic Regio- and Enantioselective Oxytrifluoromethylthiolation of Aliphatic Internal Alkenes by Neighboring Group Assistance
Xu, Jia,Zhang, Yuanyuan,Qin, Tian,Zhao, Xiaodan
, p. 6384 - 6388 (2018/10/09)
Chiral selenide-catalyzed oxytrifluoromethylthiolation of aliphatic internal alkenes by a formally intermolecular strategy is disclosed, affording CF3S 1,3-amino alcohol and 1,3-diol derivatives with high regio-, enantio-, and diastereoselectivities. The reactions are promoted by a neighboring imide or ester group on substrates via a six-membered ring transition state. This assistance strategy is also successfully applied to the regio- and diastereoselective oxyhalofunctionalization of internal alkenes and the conversion of alkynes.
