3700-19-4

Usage

Uses

Used in Pharmaceutical Industry:
Bis(Trifluoromethyl) Aniline is used as a building block for the synthesis of pharmaceuticals, contributing to the development of new drugs and improving the efficacy and safety of existing medications.
Used in Agrochemical Industry:
Bis(Trifluoromethyl) Aniline is used as a building block for the synthesis of agrochemicals, helping to create more effective and environmentally friendly pesticides and other agricultural products.
Used in Dye Industry:
Bis(Trifluoromethyl) Aniline is used as a building block for the synthesis of dyes, enabling the production of a wide range of colors and improving the performance of dye-based products.
Used in Organic Chemistry:
Bis(Trifluoromethyl) Aniline is used as a reagent for the formation of various carbon-carbon and carbon-nitrogen bonds, facilitating the synthesis of complex organic molecules and compounds.
Used in Metal-Catalyzed Reactions:
Bis(Trifluoromethyl) Aniline is used as a ligand in metal-catalyzed reactions, enhancing the efficiency and selectivity of these processes and enabling the synthesis of a broader range of chemical products.
Used in Polymer Synthesis:
Bis(Trifluoromethyl) Aniline is used as a stabilizer in polymer synthesis, improving the properties and performance of polymer-based materials and products.

InChI:InChI=1/C8H5F6N/c9-7(10,11)15(8(12,13)14)6-4-2-1-3-5-6/h1-5H

Upstream product

• 371-71-1 Perfluoro-2-azapropen 
• 359-63-7 N,N-bis(trifluoromethyl)hydroxylamine 
• 118-92-3 anthranilic acid 
• 110-46-3 isopentyl nitrite 
• 75826-04-9 trans-6-bromo-NN-bistrifluoromethylcyclohex-2-enylamine 
• 758-43-0 N-bromobis(trifluoromethyl)amine 
• 1165952-91-9 cyclohexa-1,3-diene 
• 6141-72-6 perfluoro(2,4-dimethyl-3-oxa-2,4-diazapentane) 
• 71-43-2 benzene 
• 10218-92-5 p-chloro-N,N-bis(trifluoromethyl)aniline 
• 1521-51-3 rac-3-bromocyclohexene 
• 3700-35-4 p-bromo-N,N-bis(trifluoromethyl)aniline 
• 110-83-8 cyclohexene 

Relevant academic research and scientific papers

A convenient synthesis of N,N-bis(trifluoromethyl)anilines

A convenient synthesis of N,N-bis(trifluoromethyl)anilines by means of dediazotation reactions of previously unknown aryldiazoniumbis(trifluoromethyl) imides in the presence of CuI salts are described. Properties and applications of N,N-bis(trifluoromethyl)anilines in syntheses of aromatic compounds containing the (CF3)2N group are presented.

PERFLUOROALKYL DERIVATIVES OF NITROGEN. PART L. SYNTHESIS OF THE AMPHETAMINE 2-AMINO-1-PROPANE

(III) X=Br; (IV) X=CHO (n.c.); (V) X=CH=CMeNO2 (n.c.); (VI) X=CH2CHMeNH2 (n.c.) Treatment of the Grignard reagent derived from the bromo-compound (III) with dimethyl formamide affords the corresponding aldehyde (IV) which undergoes ready condens

Polyfluoroalkyl Derivatives of Nitrogen. Part 48. The Addition of N-Halogenoamines (CF3)2NX to Cyclohexa-1,3- and -1,4-dienes; a New Synthesis of NN-Bistrifluoromethylaniline.

Treatment of cyclohexa-1,3-diene with the N-halogenoamines (CF3)2NX (X=Cl or Br) at -78 deg C gives a mixture of the 1:1 adducts, trans- and cis- and trans-; in contrast (CF3)2NI affords the former adduct exclusively.All three amines react with cyclohexa-1,4-diene under analogous conditions to yield the 1:1 adduct trans- only.Dehydrohalogenation of the 1,3-diene adducts (X=Cl or Br) with various bases (KOH powder, PriONa, ButOK) affords a mixture of 1-and 2-(NN-bistrifluoromethylamino)cyclohexa-1,3-diene.The latter diene forms a Diels-Alder adduct with trifluoronitrosomethane and the diene mixture dehydrogenates readily over a Pd-C catalyst at 180-190 deg C to give NN-bistrifluoromethylaniline exclusively in high yield.