37040-46-3

Usage

Uses

Used in Pharmaceutical Industry:
8-BROMO-1,3,4,5-TETRAHYDRO-2H-1,5-BENZODIAZEPIN-2-ONE is used as an intermediate compound for the synthesis of bromobenzodiazepinones. These bromobenzodiazepinones are important in the development of new drugs and pharmaceuticals, particularly those targeting the central nervous system.
8-BROMO-1,3,4,5-TETRAHYDRO-2H-1,5-BENZODIAZEPIN-2-ONE is used in the preparation of bromobenzodiazepinones by direct electrophilic bromination of tetrahydrobenzodiazepinones. This process allows for the creation of new benzodiazepine derivatives with potential therapeutic applications, such as anxiolytics, sedatives, hypnotics, and muscle relaxants.

Upstream product

• 5755-07-7 2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one 
• 364-73-8 4-Bromo-1-fluoro-2-nitrobenzene 
• 3196-73-4 methyl 3-aminopropanoate hydrochloride 
• 1250649-95-6 C₁₀H₁₃BrN₂O₂ 

Relevant academic research and scientific papers

Bromination of aromatic ring of tetrahydro-1,5-benzodiazepin-2-ones

Novel mono- or dibromo-substituted tetrahydro-1,5-benzodiazepinones were obtained by direct bromination of the corresponding 2,3,4,5-tetrahydro-(1H)-1,5-benzodiazepin-2-ones and 5-N-alkyl (or formyl) derivatives with bromine. Substituent effects and the o

AMINO SUBSTITUTED DIARYL[A,D]CYCLOHEPTENE ANALOGS AS MUSCARINIC AGONISTS AND METHODS OF TREATMENT OF NEUROPSYCHIATRIC DISORDERS

Disclosed herein are analogs of clozapine and pharmaceutically acceptable salts, esters, amides, or prodrugs thereof; methods of synthesizing the analogs; and methods of using the analogs for treating neuorpsychiatric disorders. In some embodiments, the analogs are amino substituted diaryl[a,d]cycloheptenes.

USE OF N-DESMETHYLCLOZAPINE AND RELATED COMPOUNDS AS DOPAMINE STABILIZING AGENTS

Disclosed herein is the use of N-desmethylclozapine (NDMC) and related compounds to treat a variety of neuropsychiatric diseases including psychosis. It is shown that NDMC and related compounds are agonists or partial agonists at D2 and D3 dopamine receptors and thus may be effective as a dopamine stabilizing agent, allowing it to be used to treat or provide reduced incidence of Extrapyramidal symptoms (EPS) and/or tardive dyskinesias (TD). Also disclosed is administering NDMC and related compounds in combination with other anti-psychotic agents.

AMINO SUBSTITUTED DIARYL[A,D]CYCLOHEPTENE ANALOGS AS MUSCARINIC AGONISTS AND METHODS OF TREATMENT OF NEUROPSYCHIATRIC DISORDERS

Disclosed herein are analogs of clozapine and pharmaceutically acceptable salts, esters, amides, or prodrugs thereof; methods of synthesizing the analogs; and methods of using the analogs for treating neuorpsychiatric disorders. In some embodiments, the analogs are amino substituted diaryl[a,d]cycloheptenes.