3705-87-1Relevant academic research and scientific papers
CRBN LIGANDS AND USES THEREOF
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Paragraph 00416; 00417, (2019/08/20)
The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of CRBN, and the treatment of CRBN-mediated disorders.
Synthesis and in vitro cytotoxic evaluation of some thiazolylbenzimidazole derivatives
Luo, Yu,Xiao, Feng,Qian, Shijing,Lu, Wei,Yang, Bo
experimental part, p. 417 - 422 (2011/02/26)
A novel kind of thiazolylbenzimidazole derivatives were designed and synthesized and evaluated for their antitumor activity against SMMC-7721 and A549 cell lines. Most compounds showed good antitumor activities, and compound 11b displayed remarkable in vi
Piperidine derivatives, their preparation and their therapeutic application
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, (2008/06/13)
A compound which is a piperidine derivative of general formula (I) STR1 in which R 1 represents a hydrogen atom, a linear or branched (C 1-6)alkyl group or a cyclo(C 3-8)alkyl group, X represents an oxygen atom, a sulphur atom or a group of general formul
2-(Piperazinyl)-4-pyrimidinamines
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, (2008/06/13)
Herein is disclosed 2-(1-piperazinyl)-4-pyrimidinamine derivatives, acid addition salts thereof, processes for their preparation, methods of using the derivatives and pharmaceutical compositions of the derivatives. The derivatives are distinguished most readily by having novel substituents at position 4 of the piperazinyl radical, the substituents being selected from the group consisting of 2-thiazoylyl, oxazolo(4,5-b)pyridin-2-yl and optionally substituted 1-(lower alkyl)-1H-benzimidazol-2-yl. The derivatives are useful for treating hypertension in a mammal.
