370558-21-7

Basic information

• Product Name: 1,3-dibenzyl-5-methylindolin-2-one
• Synonyms: 1,3-dibenzyl-5-methylindolin-2-one
• CAS NO: 370558-21-7
• Molecular Weight: 327.426
• Mol File: 370558-21-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1,3-dibenzyl-5-methylindolin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-dibenzyl-5-methylindolin-2-one(370558-21-7)
• EPA Substance Registry System: 1,3-dibenzyl-5-methylindolin-2-one(370558-21-7)

Safety Data

• Hazardous Substances Data: 370558-21-7(Hazardous Substances Data)

Upstream product

• 100-39-0 benzyl bromide 
• 99448-75-6 1-benzyl-5-methylindoline-2,3-dione 
• 608-05-9 5-methyl-indole-2,3-dione 
• 370558-13-7 N-(2-iodo-4-methylphenyl)cinnamamide 
• 102-92-1 Cinnamoyl chloride 
• 29289-13-2 2-iodo-4-methylaniline 
• 42198-68-5 α-deuteriocinnamic acid 
• 21788-36-3 (Z)-methyl 2-bromo-3-phenylacrylate 
• 55836-65-2 methyl (α-deuterio)cinnamate 
• 370558-37-5 N-(2-iodo-4-methylphenyl)-N-benzyl-(α-deuterio)cinnamide 
• 257630-75-4 N-benzyl-N-(2-iodo-4-methylphenyl)cinnamamide 

Downstream Products

• 370558-28-4 3-hydroxy-1,3-dibenzyl-5-methylindolin-2-one 

Relevant articles and documents

Candida antarctica lipase-B-catalyzed kinetic resolution of 1,3-dialkyl-3-hydroxymethyl oxindoles

Candida antarctica (CAL-B) lipase-catalyzed resolution of 1,3-dialkyl-3-hydroxymethyl oxindoles has been performed to obtain (R)-1,3-dialkyl-3-acetoxymethyl oxindoles with up to 99% ee and (S)-1,3-dialkyl-3-hydroxymethyl oxindoles with up to 78% ee using vinyl acetate as acylating agent and acetonitrile as solvent transforming (S)-3-allyl-3-hydroxymethyl oxindole to (3S)-1′-benzyl-5-(iodomethyl)-4,5-dihydro-2H-spiro[furan-3,3′-indolin]-2′-one. The optically active 3-substituted-3-hydroxymethyl oxindoles and spiro-oxindoles are among the key synthons in the synthesis of potentially biologically active molecules.