370581-32-1Relevant academic research and scientific papers
Bis(1H-2-indolyl)methanones as a novel class of inhibitors of the platelet-derived growth factor receptor kinase
Mahboobi, Siavosh,Teller, Steffen,Pongratz, Herwig,Hufsky, Harald,Sellmer, Andreas,Botzki, Alexander,Uecker, Andrea,Beckers, Thomas,Baasner, Silke,Sch?chtele, Christoph,überall, Florian,Kassack, Matthias U.,Dove, Stefan,B?hmer, Frank-D.
, p. 1002 - 1018 (2007/10/03)
The novel lead bis(1H-2-indolyl)methanone inhibits autophosphorylation of platelet-derived growth factor (PDGF) receptor tyrosine kinase in intact cells. Various substituents in the 5- or 6-position of one indole ring increase or preserve potency, whereas
2-acyl indole derivatives and their use as antitumor agents
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, (2008/06/13)
The invention relates to novel indole and heteroindole derivatives of the formula I to their tautomers, their stereoisomers, their mixtures and their salts, to their preparation and to the use of indole derivatives of the formula I as antitumor agents.
Synthetic 2-aroylindole derivatives as a new class of potent tubulin-inhibitory, antimitotic agents
Mahboobi,Pongratz,Hufsky,Hockemeyer,Frieser,Lyssenko,Paper,Bürgermeister,B?hmer,Fiebig,Burger,Baasner,Beckers
, p. 4535 - 4553 (2007/10/03)
A new class of simple synthetic antimitotic compounds based on 2-aroylindoles was discovered. (5-Methoxy-1H-2-indolyl)-phenylmethanone (1) as well as analogous 3-fluorophenyl- (36) and 3-methoxyphenyl (3) derivatives displayed high cytotoxicity of IC
