37080-10-7

Upstream product

• 4643-20-3 (E)-4-chloro-3-buten-2-one 
• 103-73-1 Phenetole 
• 10031-82-0 4-ethoxybenzaldehyde 
• 67-64-1 acetone 

Downstream Products

• 1108610-60-1 (E)-4-(4-ethoxyphenyl)-1-iodobut-3-en-2-one 
• 1185289-11-5 (1E,4E,7E)-1,8-bis(4-ethoxyphenyl)-4-(methylthio)octa-1,4,7-triene-3,6-dione 
• 1185289-09-1 (1E,4Z,7E)-1,8-bis(4-ethoxyphenyl)-4-(methylthio)octa-1,4,7-triene-3,6-dione 
• 1338577-15-3 3-O-[(E)-4-(4-ethoxyphenyl)-2-oxobut-3-en-1-yl]kaempferol 

Relevant academic research and scientific papers

FLAVONE DERIVATIVES AND THEIR PREPARATIVE METHOD AND MEDICAL USE

Flavone derivatives, preparative method of the derivatives and use thereof as medicaments for treating diabetes. The structure of the derivatives is presented by formula 1: In the structure, R1 and R2, which are identical or not, represent hydrogen atom, halogen, cyano, hydroxyl, trifluoromethyl, thio-methyl, benzyloxy, C1-C8 linear chain or branch chain alkyl, C1-C8 linear chain or branch chain alkoxy. The pharmacological test indicates that the flavone derivatives can significantly increase the glucose consumption of Hep-G2 cell with insulin resistance activity, promote translocation of glucose transporter 4 of skeletal muscle cells (L6GLUT4myc) at different level, and significantly increase glucose intake and utilization by cells. The test proves the fact for the first time that the flavone derivatives can significantly promote translocation of glucose transporter 4 of skeletal muscle cells, and one of the mechanisms for treating diabetes is activating the cell AMPK phosphorylation and phosphorylating the downstream ACC.

Synthesis and biological activity of novel tiliroside derivants

A series of new tiliroside derivatives were synthesized and characterized by analytical 1H NMR, 13C NMR and mass spectrometry. All of the compounds were evaluated for anti-diabetic properties in vitro using HepG2 cells. Compounds 3c, 3d, and 3i-l caused significant enhancements in glucose consumption by insulin-resistant HepG2 cells compared with control cells and cells that were exposed to metformin (an anti-diabetic drug). Moreover, compound 3l significantly activated adenosine 5′-monophosphate-activated protein kinase activity and reduced acetyl-CoA carboxylase activity. Thus, the tiliroside derivative 3l offers potential to be developed as a new approach for treating type II diabetes.

A concise and efficient way to synthesize polyenic diones directly from α,β-unsaturated methyl ketones

A concise and efficient approach to polyenic compounds containing important diketone structural fragments is developed from readily available α,β-unsaturated methyl ketones in the presence of copper(II) oxide, iodine, and dimethyl sulfoxide. This is a new carbon-carbon double bond-forming reaction from two methyl sp3 C-H bonds and an attractive route to introduce the SMe group into the molecule from inexpensive dimethyl sulfoxide. The hypothetic self-sorting tandem reaction mechanism is also proposed in this paper.

An efficient method for the selective iodination of ?±,?2- unsaturated ketones

An efficient approach to ?±,?2-unsaturated ?±'-iodo ketones directly from ?±,?2-unsaturated ketones by selective iodination at the ?±'-position, without effect on the double bond and the activated benzene ring, in the presence of copper (II) oxide/iodine is described. The present method has the advantages of high yields, short reaction times, inexpensive reagents, mild reaction conditions, ease of manipulation, and the formation of cleaner products. ? Georg Thieme Verlag Stuttgart ?· New York.