37080-14-1

Upstream product

• 67-64-1 acetone 
• 5736-88-9 p-butoxybenzaldehyde 

Downstream Products

• 1338577-16-4 3-O-[(E)-4-(4-butoxyphenyl)-2-oxobut-3-en-1-yl]kaempferol 
• 331665-64-6 1,5-bis(4-butoxyphenyl)penta-1,4-dien-3-one 

Relevant academic research and scientific papers

Synthesis and biological activity of novel tiliroside derivants

A series of new tiliroside derivatives were synthesized and characterized by analytical 1H NMR, 13C NMR and mass spectrometry. All of the compounds were evaluated for anti-diabetic properties in vitro using HepG2 cells. Compounds 3c, 3d, and 3i-l caused significant enhancements in glucose consumption by insulin-resistant HepG2 cells compared with control cells and cells that were exposed to metformin (an anti-diabetic drug). Moreover, compound 3l significantly activated adenosine 5′-monophosphate-activated protein kinase activity and reduced acetyl-CoA carboxylase activity. Thus, the tiliroside derivative 3l offers potential to be developed as a new approach for treating type II diabetes.